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Symbol
Name
ID 		Fmr1
fragile X messenger ribonucleoprotein 1
MGI:95564
Phenotype annotations related to behavior/neurological
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Bowel incontinence
Urinary incontinence
Depression
Autism
Obsessive-compulsive trait
Disinhibition
Hyperactivity
Attention deficit hyperactivity disorder
Recurrent hand flapping
Self-injurious behavior
Self-biting
Myalgia
Disease(s) Associated with FMR1
fragile X syndrome
fragile X-associated tremor/ataxia syndrome

Mouse Phenotypes
behavior/neurological phenotype
abnormal behavior
abnormal learning/memory/conditioning
abnormal associative learning
impaired passive avoidance behavior
impaired conditioned place preference behavior
impaired cued conditioning behavior
abnormal eye blink conditioning behavior
abnormal object recognition memory
increased exploration in new environment
abnormal spatial learning
hypodipsia
decreased aggression towards mice
increased aggression towards mice
abnormal anxiety-related response
decreased anxiety-related response
increased anxiety-related response
abnormal response to novelty
abnormal response to novel object
abnormal response to social novelty
increased grooming behavior
abnormal startle reflex
decreased startle reflex
increased startle reflex
impaired coordination
decreased grip strength
abnormal locomotor activation
increased vertical activity
decreased locomotor activity
increased locomotor activity
hyperactivity
increased stereotypic behavior
abnormal circadian behavior
increased thermal nociceptive threshold
abnormal social investigation
social withdrawal
abnormal vocalization
decreased vocalization
audiogenic seizures
convulsive seizures
tonic-clonic seizures
Availability Mouse Genotype
Fmr1tm1.1Ics/Fmr1tm1.1Ics
Fmr1tm1Cgr/Fmr1tm1Cgr *!
Fmr1tm1Cgr/Y *! ! ! ! ! ! ! ! ! ! ! ! !
Fmr1tm1Rbd/Y
Fmr1tm1Usdn/Y
Fmr1tm2Cgr/Y
Fmr1tm1.1Cidz/Fmr1tm1.1Cidz
Tg(Pcp2-cre)2Mpin/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory