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Symbol
Name
ID
Fbn1
fibrillin 1
MGI:95489
Phenotype annotations related to integument
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Reduced subcutaneous adipose tissue
Striae distensae
Thickened skin
Disease(s) Associated with FBN1
Marfan syndrome
Weill-Marchesani syndrome

Mouse Phenotypes
integument phenotype
decreased subcutaneous adipose tissue amount
abnormal hypodermis morphology
thick hypodermis
abnormal skin morphology
abnormal cutaneous collagen fibril morphology
abnormal cutaneous microfibril morphology
abnormal dermal layer morphology
abnormal dermis papillary layer morphology
abnormal dermis reticular layer morphology
abnormal dermis reticular layer collagen network
thick dermal layer
tight skin
abnormal skin condition
abnormal skin turgor
thick skin
skin fibrosis
abnormal skin physiology
abnormal skin tensile strength
Availability Mouse Genotype
Fbn1tm1.2Lysa/Fbn1tm1.2Lysa
Fbn1tm2.1Lysa/Fbn1tm2.1Lysa *
Fbn1tm3.1Hcd/Fbn1tm3.1Hcd
Fbn1tm3.2Lysa/Fbn1tm3.2Lysa
Fbn1tm3Rmz/Fbn1tm3Rmz
Fbn1tm1.2Lysa/Fbn1+
Fbn1tm2.1Hcd/Fbn1+
Fbn1tm3.1Hcd/Fbn1+
Fbn1tm3.2Lysa/Fbn1+
Fbn1Tsk/Fbn1+
Fbn1Tsk/Fbn1tm2Rmz

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory