Symbol
Name
ID

Fas
Fas cell surface death receptor
MGI:95484

Phenotype annotations related to homeostasis/metabolism

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Abnormal lymphocyte apoptosis

Decreased lymphocyte apoptosis

Increased circulating IgA level

Increased circulating IgE level

Decreased circulating IgG level

Increased circulating IgG level

Decreased circulating total IgM

Increased circulating IgM level

Decreased specific anti-polysaccharide antibody level

Increased circulating antibody level

Reduced delayed hypersensitivity

Elevated circulating creatinine concentration

Elevated circulating C-reactive protein concentration

Elevated circulating hepatic transaminase concentration

Reduced leukocyte alkaline phosphatase

Elevated erythrocyte sedimentation rate

Type I diabetes mellitus

Elevated sweat chloride

Dehydration

Edema

Hydrops fetalis

Joint swelling

Pulmonary edema

Fever

Abnormal circulating vitamin B12 concentration

Hypercalciuria

Hematuria

Pyuria

Proteinuria

Disease(s) Associated with FAS

autoimmune lymphoproliferative syndrome

chronic myeloid leukemia

cystic fibrosis

pre-eclampsia

rheumatoid arthritis

systemic lupus erythematosus

Mouse Phenotypes		increased blood urea nitrogen level	abnormal circulating protein level	increased circulating serum albumin level	increased circulating total protein level	joint swelling	abnormal interleukin level	increased urine protein level	albuminuria	abnormal enzyme/coenzyme activity
Availability	Mouse Genotype
	Fas^lpr/Fas^lpr									!

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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