Symbol
Name
ID

Ercc2
excision repair cross-complementing rodent repair deficiency, complementation group 2
MGI:95413

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Decreased circulating IgG level

Increased circulating IgG level

Decreased circulating antibody level

Paraproteinemia

Defective DNA repair after ultraviolet radiation damage

Hypercalcemia

Increased LDL cholesterol concentration

Hypercholesterolemia

Hypertriglyceridemia

Elevated circulating creatinine concentration

Hyperproteinemia

Elevated circulating hepatic transaminase concentration

Reduced leukocyte alkaline phosphatase

Glucose intolerance

Diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Pleural effusion

Fever

Abnormality of vitamin B12 metabolism

Increased level of L-fucose in urine

Aminoaciduria

Amyloidosis

Disease(s) Associated with ERCC2

chronic myeloid leukemia

coronary artery disease

multiple myeloma

pancreatic cancer

photosensitive trichothiodystrophy 1

stomach cancer

xeroderma pigmentosum

xeroderma pigmentosum group D

Mouse Phenotypes		abnormal DNA repair	abnormal circulating amino acid level	abnormal response to radiation	increased incidence of tumors by chemical induction
Availability	Mouse Genotype	abnormal DNA repair	abnormal circulating amino acid level	abnormal response to radiation	increased incidence of tumors by chemical induction
	Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh}
	Ercc2^tm3Jhjh/Ercc2^tm3Jhjh
	Ercc2^Mhdarco15/Ercc2⁺
	Ercc2^tm1Jhjh/Ercc2^{tm2(ERCC2)Jhjh}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23