Symbol
Name
ID

Sgca
sarcoglycan, alpha (dystrophin-associated glycoprotein)
MGI:894698

Phenotype annotations related to muscle

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Achilles tendon contracture

Ankle flexion contracture

Calf muscle hypertrophy

Calf muscle pseudohypertrophy

Scapular winging

Limb-girdle muscle atrophy

Limb-girdle muscular dystrophy

Limb-girdle muscle weakness

Flexion contracture

EMG: myopathic abnormalities

Difficulty climbing stairs

Frequent falls

Muscle weakness

Proximal muscle weakness

Gowers sign

Myotonia

Increased variability in muscle fiber diameter

Central core regions in muscle fibers

Increased endomysial connective tissue

Muscle fiber necrosis

Muscular dystrophy

Myopathy

Disease(s) Associated with SGCA

autosomal recessive limb-girdle muscular dystrophy type 2D

muscular dystrophy

Mouse Phenotypes

muscle phenotype

cardiac muscle necrosis

cardiomyopathy

increased extensor digitorum longus weight

increased soleus weight

abnormal muscle fiber morphology

abnormal sarcolemma morphology

abnormal skeletal muscle fiber morphology

centrally nucleated skeletal muscle fibers

increased muscle weight

abnormal skeletal muscle morphology

skeletal muscle fibrosis

calcified muscle

dystrophic muscle

abnormal muscle physiology

abnormal muscle contractility

impaired skeletal muscle contractility

Availability

Mouse Genotype

Sgca^tm1Eeng/Sgca^tm1Eeng

Sgca^tm1Isrd/Sgca^tm1Isrd

Sgca^tm1Kcam/Sgca^tm1Kcam

Sgca^tm2Kcam/Sgca^tm2Kcam

Sgca^tm2Kcam/Sgca^tm2Kcam
Tg(Ckmm-cre)5Khn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23