|
Symbol Name ID |
Smad4
SMAD family member 4 MGI:894293 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Hematological neoplasm |
Adenoma sebaceum |
Salivary gland neoplasm |
Breast carcinoma |
Cavernous hemangioma |
Visceral angiomatosis |
Neoplasm of the rectum |
Colon cancer |
Hamartomatous polyposis |
Juvenile gastrointestinal polyposis |
Intestinal polyposis |
Neoplasm of the stomach |
Multiple gastric polyps |
Neoplasm of the liver |
Hepatocellular carcinoma |
Neoplasm of the pancreas |
Pancreatic adenocarcinoma |
Gastrointestinal carcinoma |
Duodenal adenocarcinoma |
Pituitary adenoma |
Neoplasm of the thyroid gland |
Ovarian neoplasm |
Dysgerminoma |
Ovarian carcinoma |
Ovarian papillary adenocarcinoma |
Endometrial carcinoma |
Renal neoplasm |
Malignant genitourinary tract tumor |
Urinary tract neoplasm |
Neoplasm of the skin |
Basal cell carcinoma |
Neoplasm of the skeletal system |
Glioblastoma multiforme |
Benign neoplasm of the central nervous system |
Neuroblastoma |
Laryngeal carcinoma |
Melanoma |
| Disease(s) Associated with SMAD4 | |||||||||||||||||||||||||||||||||||||
| hereditary hemorrhagic telangiectasia | |||||||||||||||||||||||||||||||||||||
| juvenile polyposis syndrome | |||||||||||||||||||||||||||||||||||||
| juvenile polyposis-hereditary hemorrhagic telangiectasia syndrome | |||||||||||||||||||||||||||||||||||||
| Lynch syndrome | |||||||||||||||||||||||||||||||||||||
| ovarian cancer | |||||||||||||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | neoplasm |
increased intestinal adenoma incidence |
increased stomach tumor incidence |
increased ovary tumor incidence |
increased skin tumor incidence |
increased skin papilloma incidence |
increased carcinoma incidence |
increased lung tumor incidence |
increased tumor incidence |
|
| Availability | Mouse Genotype | |||||||||
| Smad4E6sad/Smad4+ | ||||||||||
| Smad4m4Mag/Smad4+ | ||||||||||
| Smad4tm1.1Rob/Smad4+ | ||||||||||
| Smad4tm2.1Cxd/Smad4tm2.1Cxd Tg(KRT5-cre)1Xya/0 (conditional) |
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| Smad4tm2.1Cxd/Smad4tm2.1Cxd Tg(Krt1-15-cre/PGR*)22Cot/0 (conditional) |
* | |||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 05/07/2024 MGI 6.23 |
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