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Symbol
Name
ID

Smad4
SMAD family member 4
MGI:894293

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Hypokalemia	Hypoalbuminemia	Elevated circulating hepatic transaminase concentration	Diabetes mellitus	Hematuria
Disease(s) Associated with SMAD4	Hypokalemia	Hypoalbuminemia	Elevated circulating hepatic transaminase concentration	Diabetes mellitus	Hematuria
hereditary hemorrhagic telangiectasia
juvenile polyposis syndrome
pancreatic cancer

Mouse Phenotypes		homeostasis/metabolism phenotype	increased circulating testosterone level	increased circulating progesterone level
Availability	Mouse Genotype	homeostasis/metabolism phenotype	increased circulating testosterone level	increased circulating progesterone level
	Tg(Amh-Smad4)1Tkw/0	*
	Amhr2^tm3(cre)Bhr/Amhr2⁺ Smad4^tm1Rob/Smad4^tm1.1Rob (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23