Symbol
Name
ID

Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
MGI:88589

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Abnormal erythrocyte enzyme concentration or activity

Increased circulating iron concentration

Abnormal circulating porphyrin concentration

Increased circulating ferritin concentration

Decreased circulating hepcidin concentration

Abnormal circulating enzyme concentration or activity

Elevated circulating hepatic transaminase concentration

Reduced uroporphyrinogen decarboxylase activity

Diabetes mellitus

Increased fecal porphyrin

Elevated hepatic iron concentration

Hepatic steatosis

Increased urinary porphobilinogen

Porphyrinuria

Corneal scarring

Scarring

Disease(s) Associated with CYP1A2

porphyria cutanea tarda

Mouse Phenotypes		cyanosis	decreased body temperature	abnormal physiological response to xenobiotic	decreased physiological sensitivity to xenobiotic	decreased incidence of tumors by chemical induction	abnormal xenobiotic pharmacokinetics
Availability	Mouse Genotype	cyanosis	decreased body temperature	abnormal physiological response to xenobiotic	decreased physiological sensitivity to xenobiotic	decreased incidence of tumors by chemical induction	abnormal xenobiotic pharmacokinetics
	Cyp1a2^tm1Dwn/Cyp1a2^tm1Dwn
	Cyp1a2^tm1Gonz/Cyp1a2^tm1Gonz

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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