Symbol
Name
ID

Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
MGI:88588

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Increased circulating IgG level

Decreased circulating antibody level

Paraproteinemia

Abnormal erythrocyte enzyme concentration or activity

Abnormality of metabolism/homeostasis

Hypercalcemia

Increased circulating iron concentration

Elevated circulating creatinine concentration

Abnormal circulating porphyrin concentration

Increased circulating ferritin concentration

Decreased circulating hepcidin concentration

Hyperproteinemia

Abnormal circulating enzyme concentration or activity

Elevated circulating hepatic transaminase concentration

Reduced leukocyte alkaline phosphatase

Reduced uroporphyrinogen decarboxylase activity

Diabetes mellitus

Type II diabetes mellitus

Insulin resistance

Elevated sweat chloride

Dehydration

Pleural effusion

Fever

Abnormality of vitamin B12 metabolism

Increased fecal porphyrin

Elevated hepatic iron concentration

Hepatic steatosis

Hypercalciuria

Hematuria

Pyuria

Decreased level of D-mannose in urine

Increased level of L-fucose in urine

Increased urinary porphobilinogen

Proteinuria

Porphyrinuria

Amyloidosis

Increased circulating free T3

Increased circulating free T4 concentration

Decreased thyroid-stimulating hormone level

Corneal scarring

Scarring

Disease(s) Associated with CYP1A1

Behcet's disease

chronic myeloid leukemia

cystic fibrosis

Graves' disease

multiple myeloma

polycystic ovary syndrome

porphyria cutanea tarda

Sjogren's syndrome

stomach cancer

systemic lupus erythematosus

type 2 diabetes mellitus

Mouse Phenotypes		homeostasis/metabolism phenotype	increased circulating alanine transaminase level	increased circulating aspartate transaminase level	decreased susceptibility to xenobiotic induced morbidity/mortality	decreased physiological sensitivity to xenobiotic	increased physiological sensitivity to xenobiotic	abnormal xenobiotic pharmacokinetics
Availability	Mouse Genotype	homeostasis/metabolism phenotype	increased circulating alanine transaminase level	increased circulating aspartate transaminase level		decreased physiological sensitivity to xenobiotic	increased physiological sensitivity to xenobiotic	abnormal xenobiotic pharmacokinetics
	Cyp1a1^tm1.1Dwn/Cyp1a1^tm1.1Dwn
	Cyp1a1^tm2.1Dwn/Cyp1a1^tm2.1Dwn	*
	Cyp1a1^tm3.1Dwn/Cyp1a1^tm3.1Dwn
	Cyp1a1^tm4.1Dwn/Cyp1a1^tm4.1Dwn

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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