|
Symbol Name ID |
Cyp11b1
cytochrome P450, family 11, subfamily b, polypeptide 1 MGI:88583 |
| Darker colors indicate more annotations |
| Human Phenotypes | Hyperkalemia |
Hypokalemia |
Hyponatremia |
Elevated circulating creatinine concentration |
Elevated circulating hepatic transaminase concentration |
Hypoglycemia |
Type I diabetes mellitus |
Type II diabetes mellitus |
Insulin resistance |
Metabolic acidosis |
Proximal renal tubular acidosis |
Hypokalemic alkalosis |
Dehydration |
Edema |
Pulmonary edema |
Fever |
Recurrent fever |
Decreased urinary potassium |
Hypercalciuria |
Renal salt wasting |
Proteinuria |
Increased circulating androstenedione concentration |
Increased circulating dehydroepiandrosterone-sulfate concentration |
Increased serum testosterone level |
Increased circulating 17 hydroxypregnenolone concentration |
Elevated circulating 17-hydroxyprogesterone concentration |
Elevated circulating 21-deoxycortisol concentration |
Elevated serum 11-deoxycortisol |
| Disease(s) Associated with CYP11B1 | ||||||||||||||||||||||||||||
| congenital adrenal hyperplasia | ||||||||||||||||||||||||||||
| primary hyperaldosteronism | ||||||||||||||||||||||||||||
| Disease(s) Associated with CYP11B2 | ||||||||||||||||||||||||||||
| corticosterone methyloxidase deficiency 1 | ||||||||||||||||||||||||||||
| pre-eclampsia | ||||||||||||||||||||||||||||
| primary hyperaldosteronism | ||||||||||||||||||||||||||||
| type 2 diabetes mellitus | ||||||||||||||||||||||||||||
| Mouse Phenotypes | increased circulating angiotensin II level |
decreased circulating corticosterone level |
increased circulating corticosterone level |
decreased circulating insulin level |
decreased circulating aldosterone level |
increased circulating adrenocorticotropin level |
hypokalemia |
increased circulating potassium level |
decreased circulating renin level |
increased circulating renin level |
impaired glucose tolerance |
decreased urine aldosterone level |
decreased urine corticosterone level |
increased urine progesterone level |
decreased circulating chloride level |
increased urine deoxycorticosterone level |
decreased urine osmolality |
increased urine osmolality |
abnormal enzyme/coenzyme activity |
increased renin activity |
abnormal response/metabolism to endogenous compounds |
|
| Availability | Mouse Genotype | |||||||||||||||||||||
| Cyp11b1tm1Chjk/Cyp11b1tm1Chjk | ||||||||||||||||||||||
| Cyp11b2tm1Hsk/Cyp11b2tm1Hsk | ||||||||||||||||||||||
| Cyp11b2tm2Hsk/Cyp11b2tm2Hsk | ||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/16/2024 MGI 6.23 |
|
|
|
||
Analysis Tools