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Symbol
Name
ID

Cd40lg
CD40 ligand
MGI:88337

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Increased circulating IgA level

Increased circulating IgG level

Decreased circulating antibody level

Paraproteinemia

Hypercalcemia

Increased LDL cholesterol concentration

Hypercholesterolemia

Hypertriglyceridemia

Elevated circulating creatinine concentration

Hyperproteinemia

Glucose intolerance

Diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Pleural effusion

Abnormality of vitamin B12 metabolism

Amyloidosis

Increased circulating free T3

Increased circulating free T4 concentration

Decreased thyroid-stimulating hormone level

Disease(s) Associated with CD40LG

coronary artery disease

Graves' disease

multiple myeloma

Mouse Phenotypes		homeostasis/metabolism phenotype	decreased platelet aggregation	abnormal blood coagulation	abnormal thrombosis	increased bleeding time	increased urine protein level	decreased cerebral infarct size
Availability	Mouse Genotype	homeostasis/metabolism phenotype	decreased platelet aggregation	abnormal blood coagulation	abnormal thrombosis	increased bleeding time	increased urine protein level	decreased cerebral infarct size
	Cd40lg^tm1Imx/Cd40lg^tm1Imx
	Cd40lg^tm1Imx/Y
	Tg(Igh-V-CD40lg)#Tsub/0
	Cd40lg^tm1Imx/?
	Cd40lg^tm1Parl/Cd40lg^tm1Parl Tg(Cd4-cre)1Cwi/0 (conditional)	*
	Cd40lg^tm1Parl/Cd40lg^tm1Parl Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ (conditional)	*
	Cd40lg^tm1Parl/Cd40lg^tm1Parl Tg(Tek-cre)1Ywa/0 (conditional)	*
	Cd40lg^tm1Parl/Y Commd10^{Tg(Vav1-icre)A2Kio}/Commd10⁺ (conditional)	*
	Cd40lg^tm1Parl/Y Tg(Cd4-cre)1Cwi/0 (conditional)	*
	Cd40lg^tm1Parl/Y Tg(Tek-cre)1Ywa/0 (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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