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Symbol
Name
ID
Ctnnb1
catenin (cadherin associated protein), beta 1
MGI:88276
Phenotype annotations related to integument
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Breast carcinoma
Pilomatrixoma
Generalized hypopigmentation
Neoplasm of the skin
Disease(s) Associated with CTNNB1
autosomal dominant non-syndromic intellectual disability 19
ovarian cancer
pilomatrixoma

Mouse Phenotypes
integument phenotype
increased hair follicle apoptosis
increased mammary gland tumor incidence in breeding females
squamous metaplasia of preputial gland
abnormal hair follicle melanogenesis
reduced hair shaft melanin granule number
abnormal pinna hair pigmentation
abnormal tail hair pigmentation
absent coat pigmentation
diluted coat color
abnormal hair growth
alopecia
focal hair loss
abnormal hair follicle morphology
abnormal hair follicle development
abnormal hair follicle infundibulum morphology
absent hair follicles
decreased hair follicle number
hair follicle degeneration
absent vibrissae
loss of vibrissae
abnormal hair cycle anagen phase
accelerated hair follicle regression
abnormal dermis papillary layer morphology
abnormal epidermal layer morphology
thick epidermis stratum basale
thick epidermis suprabasal layer
abnormal keratinocyte morphology
thick epidermis
skin lesions
skin fibrosis
Availability Mouse Genotype
Tg(Tyr-Ctnnb1/EGFP)#Lru/0
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Tg(Mx1-cre)1Cgn/0  (conditional)
Ctnnb1tm1Yy/Ctnnb1tm1Yy
Tg(Prrx1-cre)1Cjt/0  (conditional)
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(KRT5-rtTA)#Glk/0
Tg(tetO-cre)1Jaw/0  (conditional)
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Krt1-15-cre/PGR)22Cot/0  (conditional)
*
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(KRT14-cre/ERT)20Efu/0  (conditional)
*
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Tg(Tyr-cre)1Lru/0  (conditional)
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1(cre)Wbm/Krt14+  (conditional)
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Krt14tm1.1(cre)Wbm/Krt14+  (conditional)
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(Cryaa-cre)10Mlr/?  (conditional)
Ctnnb1tm4Wbm/Ctnnb1tm4Wbm
Tg(KRT14-cre)1Efu/0  (conditional)
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Mx1-cre)1Cgn/0  (conditional)
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Pbsn-cre)4Prb/0  (conditional)
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Tcfap2a-cre)1Will/0  (conditional)
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Msx2-rtTA)885Lma/0
Tg(tetO-cre)1Jaw/0  (conditional)
Ctnnb1tm1Mmt/Ctnnb1+
Tg(Wap-cre)11738Mam/0  (conditional)
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Foxn1-cre)1Tbo/0  (conditional)
Ctnnb1tm4Wbm/Ctnnb1+
Tg(KRT14-cre)1Efu/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory