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Symbol
Name
ID
C3
complement component 3
MGI:88227
Phenotype annotations related to homeostasis/metabolism
Darker colors indicate more annotations
Human Phenotypes
Hyperlipidemia
Increased blood urea nitrogen
Elevated serum creatinine
Fever
Hematuria
Proteinuria
Disease(s) Associated with C3
hemolytic-uremic syndrome

Mouse Phenotypes
abnormal intestinal lipid absorption
abnormal blood homeostasis
increased circulating bilirubin level
decreased circulating glucose level
decreased circulating insulin level
decreased circulating leptin level
increased circulating free fatty acid level
decreased circulating triglyceride level
increased circulating sodium level
decreased circulating interleukin-6 level
decreased circulating tumor necrosis factor level
decreased circulating alanine transaminase level
increased circulating alanine transaminase level
abnormal blood coagulation
abnormal energy expenditure
abnormal enzyme/coenzyme level
abnormal glucose homeostasis
abnormal lipid homeostasis
increased triglyceride level
abnormal tumor necrosis factor level
decreased urine albumin level
decreased cerebral infarction size
decreased susceptibility to injury
Availability Mouse Genotype
C3tm1.1(KOMP)Vlcg/C3tm1.1(KOMP)Vlcg
C3tm1Crr/C3tm1Crr
C3tm1Hrc/C3tm1Hrc

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory