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Symbol
Name
ID

Braf
Braf transforming gene
MGI:88190

Phenotype annotations related to integument

Darker colors indicate more annotations

Human Phenotypes

Low posterior hairline

Aplasia/Hypoplasia of the eyebrow

Absent eyebrow

Abnormal eyelash morphology

Sparse or absent eyelashes

Absent eyelashes

Multiple plantar creases

Palmoplantar keratoderma

Deep palmar crease

Wide intermamillary distance

Breast carcinoma

Jaundice

Atopic dermatitis

Sparse hair

Slow-growing hair

Brittle hair

Curly hair

Fine hair

Dystrophic fingernails

Hyperhidrosis

Redundant skin

Excessive wrinkled skin

Hyperextensible skin

Hyperpigmentation of the skin

Generalized hyperpigmentation

Few cafe-au-lait spots

Multiple cafe-au-lait spots

Multiple lentigines

Dry skin

Keratosis pilaris

Numerous nevi

Hyperkeratosis

Epidermal hyperkeratosis

Ichthyosis

Lentigo maligna melanoma

Disease(s) Associated with BRAF

cardiofaciocutaneous syndrome

cardiofaciocutaneous syndrome 1

Noonan syndrome 7

Noonan syndrome with multiple lentigines 3

pancreatic cancer

Mouse Phenotypes		abnormal skin sebaceous gland morphology	sparse hair	ruffled hair	long nails	nail dystrophy	skin lesions	spontaneous skin ulceration	abnormal dermal melanocyte morphology	increased skin tumor incidence	increased skin papilloma incidence
Availability	Mouse Genotype	abnormal skin sebaceous gland morphology	sparse hair	ruffled hair	long nails	nail dystrophy	skin lesions	spontaneous skin ulceration	abnormal dermal melanocyte morphology	increased skin tumor incidence	increased skin papilloma incidence
	Braf^tm1Bbd/Braf⁺
	Braf^tm1Cpri/Braf^tm1Cpri Tg(Tyr-cre/ERT2)1Lru/0 (conditional)
	Braf^tm1Cpri/Braf⁺ Scn10a^tm2(cre)Jwo/Scn10a⁺ (conditional)
	Braf^tm1Mmcm/Braf⁺ Tg(Tyr-cre/ERT2)13Bos/0 (conditional)
	Braf^tm1Tumg/Braf⁺ Tg(CAG-cre)2Osb/0 (conditional)
	Braf^tm2Cpri/Braf⁺ Tg(CMV-cre)1Cgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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