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Symbol
Name
ID
Braf
Braf transforming gene
MGI:88190
Phenotype annotations related to craniofacial
Darker colors indicate more annotations
Human Phenotypes
Low posterior hairline
Frontal bossing
Biparietal narrowing
Dolichocephaly
Micrognathia
Hypoplasia of the zygomatic bone
Macrocephaly
Relative macrocephaly
Coarse facial features
Long face
Full cheeks
Abnormality of the chin
High forehead
Narrow forehead
Prominent forehead
Deep philtrum
Long philtrum
Thick vermilion border
Submucous cleft hard palate
High palate
Open mouth
Abnormality of the dentition
Dental malocclusion
Open bite
Anteverted nares
Bulbous nose
Depressed nasal bridge
Short nose
Aplasia/Hypoplasia of the eyebrow
Absent eyebrow
Abnormal eyelash morphology
Sparse or absent eyelashes
Absent eyelashes
Long palpebral fissure
Downslanted palpebral fissures
Epicanthus
Palpebral thickening
Underdeveloped supraorbital ridges
Disease(s) Associated with BRAF
cardiofaciocutaneous syndrome
cardiofaciocutaneous syndrome 1
Noonan syndrome 7
Noonan syndrome with multiple lentigines 3

Mouse Phenotypes
abnormal basicranium morphology
decreased cranium length
abnormal neurocranium morphology
abnormal frontal bone morphology
abnormal parietal bone morphology
long incisors
mandible hypoplasia
abnormal facial morphology
round head
shortened head
Availability Mouse Genotype
Braftm1Bbd/Braf+
Braftm1Tumg/Braf+
Tg(CAG-cre)2Osb/0  (conditional)
Braftm2Cpri/Braf+
Tg(CMV-cre)1Cgn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory