|
Symbol Name ID |
Bmp4
bone morphogenetic protein 4 MGI:88180 |
| Darker colors indicate more annotations |
| Human Phenotypes | Brachycephaly |
Lambdoidal craniosynostosis |
Plagiocephaly |
Micrognathia |
Retrognathia |
Aplasia of the maxilla |
Small sella turcica |
Microcephaly |
Enamel hypoplasia |
Clinodactyly of the 5th finger |
Short middle phalanx of finger |
Proximal placement of thumb |
Thumb contracture |
Postaxial foot polydactyly |
Toe syndactyly |
Polydactyly |
Brachydactyly |
Finger syndactyly |
Abnormality of the vertebral column |
Back pain |
Increased bone mineral density |
Ectopic ossification |
| Disease(s) Associated with BMP4 | ||||||||||||||||||||||
| CAKUT2 | ||||||||||||||||||||||
| ossification of the posterior longitudinal ligament of spine | ||||||||||||||||||||||
| syndromic microphthalmia 6 | ||||||||||||||||||||||
| tooth agenesis |
| Mouse Phenotypes | enhanced osteoblast differentiation |
impaired osteoblast differentiation |
large anterior fontanelle |
frontal bone hypoplasia |
short frontal bone |
small interparietal bone |
abnormal jaw morphology |
abnormal mandible morphology |
absent mandibular angle |
absent mandibular condyloid process |
absent mandibular coronoid process |
abnormal temporomandibular joint morphology |
mandible hypoplasia |
maxilla hypoplasia |
agnathia |
retrognathia |
syngnathia |
nasal bone hypoplasia |
short nasal bone |
abnormal fibula morphology |
split xiphoid process |
decreased rib number |
short ribs |
thoracic vertebral fusion |
kyphosis |
kyphoscoliosis |
scoliosis |
cervical vertebral fusion |
abnormal vertebral spinous process morphology |
abnormal trabecular bone morphology |
ectopic bone |
|
| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||
| Bmp4tm1.1Jlch/Bmp4tm1.1Jlch | ||||||||||||||||||||||||||||||||
| Bmp4tm1.1Jlch/Bmp4tm2Blh | ||||||||||||||||||||||||||||||||
| Bmp4tm1Blh/Bmp4+ | ||||||||||||||||||||||||||||||||
| Bmp4tm2Blh/Bmp4+ | ||||||||||||||||||||||||||||||||
| Tg(Eno2-Bmp4)3Jake/0 | ||||||||||||||||||||||||||||||||
| Bmp4tm1Jfm/Bmp4tm1Jfm H2az2Tg(Wnt1-cre)11Rth/H2az2+ (conditional) |
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| Bmp4tm3Blh/Bmp4tm3Blh Foxg1tm1(cre)Skm/Foxg1+ (conditional) |
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| Bmp4tm4Blh/Bmp4tm4Blh Isl1tm1(cre)Sev/Isl1+ (conditional) |
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| H2az2Tg(Wnt1-cre)11Rth/H2az2+ Tg(CAG-Bmp4,-EGFP)1Ypc/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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