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Symbol
Name
ID
Apoe
apolipoprotein E
MGI:88057
Phenotype annotations related to homeostasis/metabolism
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Cerebral amyloid angiopathy
Disease(s) Associated with APOE
Alzheimer's disease 4

Mouse Phenotypes
homeostasis/metabolism phenotype
glomerular capillary thrombosis
increased cholesterol efflux
decreased circulating homocysteine level
decreased circulating glucose level
increased circulating corticosterone level
decreased circulating insulin level
decreased circulating leptin level
abnormal circulating lipid level
abnormal circulating cholesterol level
decreased circulating HDL cholesterol level
increased circulating HDL cholesterol level
abnormal circulating LDL cholesterol level
increased circulating LDL cholesterol level
increased circulating VLDL cholesterol level
decreased circulating cholesterol level
increased circulating cholesterol level
increased circulating phospholipid level
decreased circulating triglyceride level
increased circulating triglyceride level
hyperlipidemia
abnormal circulating protein level
improved glucose tolerance
increased insulin sensitivity
abnormal lipid homeostasis
abnormal cholesterol homeostasis
decreased liver cholesterol level
decreased cholesterol level
increased cholesterol level
abnormal lipid level
increased prostaglandin level
decreased liver triglyceride level
decreased triglyceride level
increased triglyceride level
xanthoma
abnormal enzyme/coenzyme activity
altered response to CNS ischemic injury
decreased cerebral infarction size
Availability Mouse Genotype
Apoeshl/Apoeshl ! !
ApoeTg(rtTA)1Gaga/ApoeTg(rtTA)1Gaga
Apoetm1.1Khw/Apoetm1.1Khw *
Apoetm1Bres/Apoetm1Bres
Apoetm1Khw/Apoetm1Khw
Apoetm1Lmh/Apoetm1Lmh
Apoetm1Unc/Apoetm1Unc
Apoetm1Unc/Apoetm1Unc
Tg(Cyp21a1-Apoe)614Fet/0
Apoetm1Unc/Apoetm1Unc
Tg(Cyp21a1-Apoe)619Fet/0
Apoetm2(APOE)Sfu/Apoetm2(APOE)Sfu
Apoetm4Mae/Apoetm4Mae
Apoeshl/Apoetm1Unc
Apoetm1Bres/Apoe+
Apoetm1Lmh/Apoe+
Apoetm1Unc/Apoe+
Tg(Cyp21a1-Apoe)614Fet/0
Tg(Cyp21a1-Apoe)619Fet/0
Apoetm1.1Mae/Apoetm1.1Mae
Tg(Fabp4-cre)1Rev/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/12/2019
MGI 6.13
The Jackson Laboratory