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Symbol
Name
ID

Akt1
thymoma viral proto-oncogene 1
MGI:87986

Phenotype annotations related to integument

Darker colors indicate more annotations

Human Phenotypes

Hypertrophy of skin of soles

Palmoplantar hyperkeratosis

Gynecomastia

Breast carcinoma

Fibroadenoma of the breast

Jaundice

Epidermal acanthosis

Depigmentation/hyperpigmentation of skin

Subcutaneous lipoma

Nevus

Epidermal nevus

Skin tags

Hyperkeratosis

Disease(s) Associated with AKT1

breast cancer

Cowden syndrome 6

ovarian cancer

pancreatic cancer

Proteus syndrome

Mouse Phenotypes		decreased keratinocyte proliferation	abnormal mammary gland duct morphology	mammary gland alveolar hyperplasia	abnormal mammary gland stroma morphology	mammary gland hyperplasia	thin hypodermis	underdeveloped hair follicles	epidermal hyperplasia	pallor	increased trichoepithelioma incidence
Availability	Mouse Genotype	decreased keratinocyte proliferation	abnormal mammary gland duct morphology	mammary gland alveolar hyperplasia	abnormal mammary gland stroma morphology	mammary gland hyperplasia	thin hypodermis	underdeveloped hair follicles	epidermal hyperplasia	pallor	increased trichoepithelioma incidence
	Akt1^tm1Hem/Akt1^tm1Hem
	Akt1^tm1.1Mjl/Akt1⁺
	Tg(KRT5-Akt1*)Jmpa/0
	Akt1^tm1Mjl/Akt1⁺ Gt(ROSA)26Sor^{tm1(cre/ERT)Nat}/Gt(ROSA)26Sor^{tm1(cre/ERT)Nat} (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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