Symbol
Name
ID

Syngap1
synaptic Ras GTPase activating protein 1 homolog (rat)
MGI:3039785

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Drooling	Autistic behavior
Disease(s) Associated with SYNGAP1	Drooling	Autistic behavior
autosomal dominant intellectual developmental disorder 5

Mouse Phenotypes

behavior/neurological phenotype

increased susceptibility to pharmacologically induced seizures

impaired cued conditioning behavior

abnormal discrimination learning

abnormal spatial learning

abnormal spatial working memory

abnormal suckling behavior

decreased anxiety-related response

abnormal motor capabilities/coordination/movement

increased startle reflex

tremors

weakness

increased locomotor activity

hyperactivity

bradykinesia

increased horizontal stereotypic behavior

abnormal social/conspecific interaction behavior

social withdrawal

audiogenic seizures

Availability

Mouse Genotype

Syngap1^tm1.1Mabk/Syngap1^tm1.1Mabk

Syngap1^tm1Rlh/Syngap1^tm1Rlh

Syngap1^tm1Grnt/Syngap1⁺

Syngap1^tm1Rlh/Syngap1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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