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Symbol
Name
ID 		Dsg4
desmoglein 4
MGI:2661061
Phenotype annotations related to integument
Darker colors indicate more annotations
Human Phenotypes
Sparse scalp hair
Sparse eyebrow
Sparse eyelashes
Erythema
Alopecia
Sparse hair
Sparse body hair
Pili torti
Brittle hair
Follicular hyperkeratosis
Pruritus
Disease(s) Associated with DSG4
hypotrichosis
hypotrichosis 6

Mouse Phenotypes
decreased subcutaneous adipose tissue amount
abnormal sebaceous gland morphology
skin edema
dermatitis
abnormal coat appearance
abnormal hair growth
alopecia
focal hair loss in abdominal region
focal hair loss in head/neck region
short hair
sparse hair
abnormal hair texture
brittle hair
rough coat
greasy coat
absent guard hair
abnormal hair shaft morphology
abnormal hair cortex morphology
deformed nails
long toenails
abnormal hair follicle morphology
abnormal hair follicle inner root sheath morphology
hair follicle outer root sheath hyperplasia
distorted hair follicle pattern
enlarged hair follicles
hair follicle degeneration
absent vibrissae
short vibrissae
wavy vibrissae
abnormal hair cycle anagen phase
abnormal hair cycle catagen phase
mixed cellular infiltration to dermis
thick dermal layer
hyperkeratosis
parakeratosis
acanthosis
epidermal hyperplasia
thick epidermis
reddish skin
scaly skin
wrinkled skin
abnormal skin pigmentation
abnormal skin condition
thick skin
decreased skin tensile strength
Availability Mouse Genotype
Dsg4arm/Dsg4arm
Dsg4lah-J/Dsg4lah-J
Dsg4lah/Dsg4lah
Dsg4m1Btlr/Dsg4m1Btlr
Dsg4tbird/Dsg4tbird
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory