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Symbol
Name
ID

Disc1
disrupted in schizophrenia 1
MGI:2447658

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Negativism	Lack of spontaneous play	Impaired ability to form peer relationships	Autism	Autism with high cognitive abilities	Inflexible adherence to routines	Motor stereotypy	Restrictive behavior
Disease(s) Associated with DISC1	Negativism	Lack of spontaneous play	Impaired ability to form peer relationships	Autism	Autism with high cognitive abilities	Inflexible adherence to routines	Motor stereotypy	Restrictive behavior
Asperger syndrome
autistic disorder
schizophrenia

Mouse Phenotypes

behavior/neurological phenotype

abnormal learning/memory/conditioning

impaired passive avoidance behavior

enhanced contextual conditioning behavior

abnormal latent inhibition of conditioning behavior

decreased exploration in new environment

increased exploration in new environment

abnormal spatial learning

abnormal spatial working memory

abnormal liquid preference

behavioral despair

decreased anxiety-related response

increased anxiety-related response

increased thigmotaxis

abnormal response to novel object

abnormal impulsive behavior control

decreased startle reflex

decreased vertical activity

increased locomotor activity

hyperactivity

induced hyperactivity

abnormal social/conspecific interaction behavior

abnormal social investigation

social withdrawal

decreased vocalization

Availability

Mouse Genotype

Disc1^del/Disc1^del

Disc1^em1(IMPC)Mbp/Disc1^em1(IMPC)Mbp

Disc1^m1H/Disc1^m1H

*

Disc1^Rgsc1390/Disc1^Rgsc1390

*

Disc1^Rgsc1393/Disc1^Rgsc1393

*

Disc1^tm1Kara/Disc1^tm1Kara

Disc1^tm1Kozo/Disc1^tm1Kozo

*

Disc1^Rgsc1390/Disc1⁺

*

Disc1^Rgsc1390/Disc1^Rgsc1393

Disc1^Rgsc1393/Disc1⁺

Disc1^tm1Kara/Disc1⁺

Tg(Camk2a-ESR1/Disc1*)2698.1Sva/0

Tg(Disc1/EGFP)M19Sshe/0

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23