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Symbol
Name
ID
Lrp4
low density lipoprotein receptor-related protein 4
MGI:2442252
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Abnormality of dental enamel
Micrognathia
Mandibular prognathia
Malar flattening
Macrocephaly
Frontal bossing
Short thumb
Short finger
Foot oligodactyly
Toe syndactyly
Oligodactyly
Syndactyly
Cutaneous finger syndactyly
Finger syndactyly
Hypoplasia of the radius
Hypoplasia of the ulna
Radioulnar synostosis
Abnormality of the metacarpal bones
Hip dislocation
Synostosis of carpal bones
Elbow dislocation
Micromelia
Abnormality of the ribs
Abnormal form of the vertebral bodies
Scoliosis
Synostosis of joints
Disease(s) Associated with LRP4
Cenani-Lenz syndactyly syndrome
sclerosteosis 2

Mouse Phenotypes
skeleton phenotype
thick neurocranium
abnormal tooth morphology
abnormal incisor morphology
supernumerary incisors
abnormal molar cusp morphology
abnormal tooth development
abnormal enamel morphology
fused phalanges
increased femur compact bone thickness
increased diameter of femur
fused metacarpal bones
fused metatarsal bones
abnormal spine curvature
increased trabecular bone volume
abnormal osteocyte morphology
increased bone trabecula number
decreased bone trabecular spacing
increased trabecular bone connectivity density
increased trabecular bone thickness
abnormal chondrocyte morphology
increased bone ossification
increased bone strength
Availability Mouse Genotype
Lrp4mdig-2J/Lrp4mdig-2J
Lrp4mdig-3J/Lrp4mdig-3J
Lrp4mitt/Lrp4mitt
Lrp4mte/Lrp4mte
Lrp4tm1.1Pg/Lrp4tm1.1Pg *
Lrp4tm1Her/Lrp4tm1Her
Lrp4tm2Her/Lrp4tm2Her
Lrp4tm1.1Pg/Lrp4+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/13/2020
MGI 6.16
The Jackson Laboratory