Symbol
Name
ID

Dicer1
dicer 1, ribonuclease type III
MGI:2177178

Phenotype annotations related to integument

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Pilomatrixoma	Basal cell carcinoma
Disease(s) Associated with DICER1	Pilomatrixoma	Basal cell carcinoma
multinodular goiter

Mouse Phenotypes

integument phenotype

epidermal cyst

abnormal coat/ hair morphology

abnormal hair growth

alopecia

delayed hair appearance

progressive hair loss

waved hair

abnormal hair shaft morphology

abnormal hair follicle morphology

small hair follicle bulb

abnormal hair follicle development

abnormal hair follicle inner root sheath morphology

abnormal hair follicle orientation

abnormal hair follicle bulge morphology

decreased hair follicle number

hair follicle degeneration

small hair follicles

abnormal vibrissa morphology

loss of vibrissae

abnormal hair cycle catagen phase

abnormal hair follicle regression

decreased hair follicle cell proliferation

abnormal epidermal layer morphology

epidermal hyperplasia

thick epidermis

abnormal skin appearance

dry skin

scaly skin

abnormal skin physiology

Availability

Mouse Genotype

Dicer1^tm1Smr/Dicer1^tm1Smr
Tg(KRT14-cre)52Smr/0 (conditional)

Dicer1^tm1Smr/Dicer1^tm1Smr
Tg(KRT5-rtTA)1Glk/0
Tg(tetO-cre)1Jaw/0 (conditional)

Dicer1^tm1Snj/Dicer1^tm1Snj
Tg(KRT5-cre/PGR)1Der/0 (conditional)

Dicer1^tm1Tara/Dicer1^tm1Tara
Tg(KRT14-cre)1Efu/? (conditional)

Dicer1^tm1Tara/Dicer1^tm1Tara
Tg(KRT14-cre)1Efu/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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