Symbol
Name
ID

Dock2
dedicator of cyto-kinesis 2
MGI:2149010

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Reduced antigen-specific T cell proliferation	T lymphocytopenia	Focal active colitis	Recurrent otitis media	Eosinophilic granuloma	Chronic oral candidiasis	Recurrent pneumonia	Combined immunodeficiency	Severe varicella zoster infection
Disease(s) Associated with DOCK2
immunodeficiency 40

Mouse Phenotypes

immune system phenotype

impaired neutrophil chemotaxis

abnormal leukocyte migration

increased spleen weight

abnormal B cell differentiation

abnormal class switch recombination

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

increased neutrophil cell number

decreased mature B cell number

decreased B-1a cell number

decreased B-1b cell number

decreased marginal zone B cell number

increased B-1 B cell number

decreased B cell number

increased B cell number

decreased NK cell number

increased NK cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

abnormal CD8-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

increased alpha-beta T cell number

decreased T cell number

decreased single-positive T cell number

increased single-positive T cell number

decreased lymphocyte cell number

increased macrophage cell number

abnormal lymphocyte morphology

abnormal T cell morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha-beta cytotoxic T cell morphology

abnormal spleen morphology

spleen hypoplasia

abnormal spleen white pulp morphology

decreased IgE level

increased IgE level

decreased IgG level

abnormal immune system morphology

abnormal Peyer's patch morphology

lymph node hypoplasia

abnormal immune system physiology

abnormal humoral immune response

decreased response to antigen

Availability

Mouse Genotype

Dock2^m1Anu/Dock2^m1Anu

Dock2^m1Btlr/Dock2^m1Btlr

Dock2^m2Anu/Dock2^m2Anu

Dock2^m2Btlr/Dock2^m2Btlr

Dock2^m3Anu/Dock2^m3Anu

Dock2^m3Btlr/Dock2^m3Btlr

Dock2^m4Btlr/Dock2^m4Btlr

Dock2^m5Btlr/Dock2^m5Btlr

Dock2^m6Btlr/Dock2^m6Btlr

Dock2^m7Btlr/Dock2^m7Btlr

Dock2^m8Btlr/Dock2^m8Btlr

Dock2^M9Btlr/Dock2^M9Btlr

Dock2^m10Btlr/Dock2^m10Btlr

Dock2^m11Btlr/Dock2^m11Btlr

Dock2^M12Btlr/Dock2^M12Btlr

Dock2^m13Btlr/Dock2^m13Btlr

Dock2^M14Btlr/Dock2^M14Btlr

Dock2^m15Btlr/Dock2^m15Btlr

Dock2^M16Btlr/Dock2^M16Btlr

Dock2^{tm1b(EUCOMM)Wtsi}/Dock2^{tm1b(EUCOMM)Wtsi}

Dock2^tm1Tsas/Dock2^tm1Tsas

Dock2^m5Btlr/Dock2⁺

Dock2^m7Btlr/Dock2⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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