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Name
ID

Crb1
crumbs family member 1, photoreceptor morphogenesis associated
MGI:2136343

Phenotype annotations related to vision/eye

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Abnormal retinal vascular morphology

Attenuation of retinal blood vessels

Keratoconus

Cataract

Posterior subcapsular cataract

Chorioretinal atrophy

Choriocapillaris atrophy

Paravenous chorioretinal atrophy

Abnormal optic disc morphology

Optic atrophy

Optic disc pallor

Macular coloboma

Abnormality of retinal pigmentation

Pigmentary retinopathy

Bone spicule pigmentation of the retina

Nummular pigmentation of the fundus

Retinal degeneration

Rod-cone dystrophy

Vitreoretinopathy

Deeply set eye

Abnormal electroretinogram

Undetectable electroretinogram

Esotropia

Exotropia

Nystagmus

Ophthalmoplegia

Hypermetropia

High hypermetropia

Color vision defect

Nyctalopia

Progressive night blindness

Photophobia

Photopsia

Visual impairment

Reduced visual acuity

Blindness

Severely reduced visual acuity

Peripheral visual field loss

Glaucoma

Disease(s) Associated with CRB1

cone-rod dystrophy

Leber congenital amaurosis

Leber congenital amaurosis 8

pigmented paravenous chorioretinal atrophy

retinitis pigmentosa

retinitis pigmentosa 12

Mouse Phenotypes

vision/eye phenotype

abnormal retina vasculature morphology

retina neovascularization

photosensitivity

abnormal Muller cell morphology

decreased retina photoreceptor cell number

abnormal retina photoreceptor morphology

abnormal photoreceptor inner segment morphology

short photoreceptor inner segment

short photoreceptor outer segment

photoreceptor outer segment degeneration

retina photoreceptor degeneration

abnormal retina pigment epithelium morphology

abnormal retina pigmentation

abnormal ocular fundus morphology

abnormal retina morphology

abnormal retina inner nuclear layer morphology

abnormal retina outer nuclear layer morphology

thin retina outer nuclear layer

abnormal retina photoreceptor layer morphology

abnormal retina outer limiting membrane morphology

retina degeneration

retina fold

retina spots

Availability

Mouse Genotype

Crb1^em1Jnk/Crb1^em1Jnk

Crb1^em2Jnk/Crb1^em2Jnk

Crb1^em3Jnk/Crb1^em3Jnk

Crb1^em4Jnk/Crb1^em4Jnk

Crb1^rd8/Crb1^rd8

*!

!

Crb1^tm1Wij/Crb1^tm1Wij

Crb1^rd8+em1Mvw/Crb1^rd8

*

Crb1^tm1Wij/Crb1^tm2Wij

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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