Symbol
Name
ID

Sirt1
sirtuin 1
MGI:2135607

Phenotype annotations related to cellular

Darker colors indicate more annotations

Mouse Phenotypes

abnormal sperm flagellum morphology

oligozoospermia

teratozoospermia

globozoospermia

abnormal spermatid morphology

abnormal spermatocyte morphology

multinucleated giant male germ cells

abnormal chromosome morphology

aneuploidy

abnormal cell cycle checkpoint function

increased mitotic index

abnormal cell death

increased cellular sensitivity to ionizing radiation

increased cellular sensitivity to gamma-irradiation

increased cellular sensitivity to ultraviolet irradiation

increased male germ cell apoptosis

immotile sperm

abnormal cellular respiration

abnormal DNA repair

abnormal DNA replication

Availability

Mouse Genotype

Sirt1^tm1.1Cxd/Sirt1^tm1.1Cxd

Sirt1^tm1Fwa/Sirt1^tm1Fwa

Sirt1^tm1Mcby/Sirt1^tm1Mcby

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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