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Symbol
Name
ID

Sirt1
sirtuin 1
MGI:2135607

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Depression	Personality changes
Disease(s) Associated with SIRT1	Depression	Personality changes
Huntington's disease

Mouse Phenotypes		behavior/neurological phenotype	lethargy	polydipsia	decreased food intake	increased food intake	polyphagia	decreased locomotor activity	hyperactivity	hypoactivity in response to feed restriction	abnormal nursing
Availability	Mouse Genotype	behavior/neurological phenotype	lethargy	polydipsia	decreased food intake	increased food intake	polyphagia	decreased locomotor activity	hyperactivity	hypoactivity in response to feed restriction	abnormal nursing
	Sirt1^tm1Mcby/Sirt1^tm1Mcby
	Sirt1^tm2.1Fwa/Sirt1^tm2.1Fwa
	Tg(Sirt1)ASrn/?
	Sirt1^tm3Fwa/Sirt1^tm3Fwa Tg(Nes-cre)1Kln/0 (conditional)
	Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Pomc1-cre)16Lowl/0 (conditional)	*
	Gt(ROSA)26Sor^{tm1(Sirt1)Ktm}/Gt(ROSA)26Sor⁺ Tg(Agrp-cre)1Gsb/0 (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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