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Symbol
Name
ID

Manf
mesencephalic astrocyte-derived neurotrophic factor
MGI:1922090

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Elevated circulating hepatic transaminase concentration	Diabetes mellitus
Disease(s) Associated with MANF	Elevated circulating hepatic transaminase concentration	Diabetes mellitus
pancreatic cancer

Mouse Phenotypes		homeostasis/metabolism phenotype	abnormal translation	hyperglycemia	decreased circulating insulin level	abnormal glucose homeostasis
Availability	Mouse Genotype	homeostasis/metabolism phenotype	abnormal translation	hyperglycemia	decreased circulating insulin level	abnormal glucose homeostasis
	Manf^{tm1a(KOMP)Wtsi}/Manf^{tm1a(KOMP)Wtsi}
	Manf^{tm1c(KOMP)Wtsi}/Manf^{tm1c(KOMP)Wtsi} (conditional)
	Manf^{tm1c(KOMP)Wtsi}/Manf^{tm1c(KOMP)Wtsi} Tg(Nes-cre)1Kln/0 (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23