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Symbol
Name
ID
Sost
sclerostin
MGI:1921749
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Mandibular prognathia
Frontal bossing
Malar flattening
Craniofacial hyperostosis
Facial hyperostosis
Facial palsy secondary to cranial hyperostosis
Micrognathia
Craniofacial osteosclerosis
Calvarial osteosclerosis
Macrocephaly
Sagittal craniosynostosis
Scaphocephaly
Cranial hyperostosis
Sclerosis of skull base
Club-shaped distal femur
Erlenmeyer flask deformity of the femurs
Broad phalanx of the toes
Broad distal phalanx of finger
Short distal phalanx of finger
Patchy sclerosis of finger phalanx
Deviation of finger
Sandal gap
Postaxial polydactyly
Brachydactyly
Syndactyly
Cutaneous finger syndactyly
2-3 finger syndactyly
Abnormality of the metaphysis
Metaphyseal dysplasia
Metaphyseal widening
Flared metaphysis
Diaphyseal dysplasia
Diaphyseal sclerosis
Thickened cortex of long bones
Cortically dense long tubular bones
Abnormality of pelvic girdle bone morphology
Hip dysplasia
Abnormality of the thorax
Broad clavicles
Broad ribs
Thickened ribs
Sclerotic scapulae
Pectus excavatum
Narrow chest
Abnormality of the vertebral column
Sclerotic vertebral endplates
Increased bone mineral density
Osteopetrosis
Joint hypermobility
Joint laxity
Skeletal dysplasia
Disease(s) Associated with SOST
craniometaphyseal dysplasia
sclerosteosis 1
SOST-related sclerosing bone dysplasia

Mouse Phenotypes
skeleton phenotype
decreased osteocyte apoptosis
decreased osteoblast apoptosis
abnormal osteoblast physiology
long femur
increased bone mineral content
increased bone mineral density
increased compact bone volume
increased trabecular bone volume
increased bone volume
abnormal compact bone morphology
increased compact bone area
increased compact bone mass
increased compact bone thickness
abnormal osteoblast morphology
increased osteocyte number
abnormal trabecular bone morphology
increased bone trabecula number
increased trabecular bone connectivity density
increased trabecular bone mass
increased trabecular bone thickness
increased bone mass
abnormal bone ossification
abnormal bone mineralization
abnormal bone remodeling
increased bone stiffness
increased bone strength
Availability Mouse Genotype
Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg *
Sosttm1Dgen/Sosttm1Dgen
Sosttm1Lhe/Sosttm1Lhe
Sosttm1Paz/Sosttm1Paz
Sosttm1(KOMP)Vlcg/Sosttm2.1Vlcg
Tg(Nanog-cre)#Vlcg/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory