|
Symbol Name ID |
Sost
sclerostin MGI:1921749 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Frontal bossing |
Craniofacial hyperostosis |
Facial palsy secondary to cranial hyperostosis |
Mandibular prognathia |
Malar flattening |
Craniofacial osteosclerosis |
Large sella turcica |
Macrocephaly |
Diaphyseal sclerosis |
Deviation of finger |
Syndactyly |
2-3 finger syndactyly |
Cortically dense long tubular bones |
Abnormal pelvic girdle bone morphology |
Broad clavicles |
Broad ribs |
Thickened ribs |
Sclerotic scapulae |
Sclerotic vertebral endplates |
Cortical sclerosis |
| Disease(s) Associated with SOST | ||||||||||||||||||||
| autosomal dominant craniodiaphyseal dysplasia | ||||||||||||||||||||
| sclerosteosis 1 |
| Mouse Phenotypes | skeleton phenotype |
decreased osteocyte apoptosis |
decreased osteoblast apoptosis |
abnormal osteoblast physiology |
long femur |
increased bone mineral density of lumbar vertebrae |
increased bone mineral content |
increased areal bone mineral density |
increased bone mineral density of femur |
increased bone mineral density |
increased compact bone volume |
increased trabecular bone volume |
increased bone volume |
abnormal compact bone morphology |
increased compact bone area |
increased compact bone mass |
increased compact bone thickness |
abnormal osteoblast morphology |
increased osteocyte number |
abnormal trabecular bone morphology |
increased bone trabecula number |
increased trabecular bone connectivity density |
increased trabecular bone mass |
increased trabecular bone thickness |
increased bone mass |
abnormal bone ossification |
abnormal bone mineralization |
abnormal bone remodeling |
increased bone stiffness |
increased bone strength |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Sosttm1(KOMP)Vlcg/Sosttm1(KOMP)Vlcg | * | ||||||||||||||||||||||||||||||
| Sosttm1Dgen/Sosttm1Dgen | |||||||||||||||||||||||||||||||
| Sosttm1Lex/Sosttm1Lex | |||||||||||||||||||||||||||||||
| Sosttm1Lhe/Sosttm1Lhe | |||||||||||||||||||||||||||||||
| Sosttm1Paz/Sosttm1Paz | |||||||||||||||||||||||||||||||
| Sosttm1(KOMP)Vlcg/Sosttm2.1Vlcg Tg(Nanog-cre)#Vlcg/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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