Symbol
Name
ID

Opa1
OPA1, mitochondrial dynamin like GTPase
MGI:1921393

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Decreased activity of mitochondrial complex I	Decreased activity of mitochondrial complex IV	Hyperalaninemia	Increased CSF lactate	Diabetes mellitus	Increased circulating lactate concentration	Basal ganglia calcification
Disease(s) Associated with OPA1	Decreased activity of mitochondrial complex I	Decreased activity of mitochondrial complex IV	Hyperalaninemia	Increased CSF lactate	Diabetes mellitus	Increased circulating lactate concentration	Basal ganglia calcification
mitochondrial DNA depletion syndrome 14
optic atrophy

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal autophagy

abnormal mitophagy

decreased insulin secretion

increased creatine level

increased circulating glucose level

decreased circulating insulin level

edema

decreased oxygen consumption

impaired glucose tolerance

abnormal enzyme/coenzyme activity

decreased susceptibility to injury

Availability

Mouse Genotype

Opa1^M1Bewi/Opa1^M1Bewi

Opa1^tm1.1Geno/Opa1⁺

Hprt1^{tm1(ACTB-Opa1)Lsc}/Y

Opa1^tm1.1Hise/Opa1^tm1.2Hise
Tg(Ins2-cre)25Mgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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