Symbol
Name
ID

Cox15
cytochrome c oxidase assembly protein 15
MGI:1920112

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Decreased activity of mitochondrial respiratory chain

Decreased activity of mitochondrial complex I

Decreased activity of mitochondrial complex II

Decreased activity of mitochondrial complex III

Decreased activity of mitochondrial complex IV

Decreased activity of the pyruvate dehydrogenase complex

Hyperalaninemia

Increased CSF lactate

Abnormal circulating enzyme concentration or activity

Decreased circulating biotinidase concentration

Hypoglycemia

Increased circulating lactate concentration

Ketoacidosis

Lactic acidosis

Renal tubular acidosis

Hepatic steatosis

3-Methylglutaconic aciduria

Ethylmalonic aciduria

Methylmalonic aciduria

Generalized aminoaciduria

Lacticaciduria

Complex organic aciduria

Disease(s) Associated with COX15

Leigh disease

mitochondrial complex IV deficiency nuclear type 6

Mouse Phenotypes		increased circulating alanine transaminase level	increased circulating aspartate transaminase level	increased susceptibility to xenobiotic induced morbidity/mortality	increased physiological sensitivity to xenobiotic
Availability	Mouse Genotype	increased circulating alanine transaminase level	increased circulating aspartate transaminase level		increased physiological sensitivity to xenobiotic
	Cox15^{tm1.1(KOMP)Vlcg}/Cox15⁺
	Cox15^tm1.1Zev/Cox15^tm1.1Zev Tg(ACTA1-cre)79Jme/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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