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Symbol
Name
ID 		Amer1
APC membrane recruitment 1
MGI:1919595
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Frontal bossing
Flat occiput
Brachycephaly
Facial hyperostosis
Thickened calvaria
Micrognathia
Retrognathia
Paranasal sinus hypoplasia
Craniofacial osteosclerosis
Sclerosis of skull base
Macrocephaly
Delayed cranial suture closure
Delayed closure of the anterior fontanelle
Large fontanelles
Clinodactyly of the 5th finger
Arachnodactyly
Flexion contracture of toe
Fibular aplasia
Fibular hypoplasia
Abnormal metaphysis morphology
Coarse metaphyseal trabecularization
Osteopathia striata
Joint contracture of the hand
Camptodactyly
High iliac wing
Large iliac wing
Straight clavicles
Broad ribs
Asymmetry of the thorax
Pectus excavatum
Thoracolumbar kyphosis
Hyperlordosis
Scoliosis
Increased bone mineral density
Osteopetrosis
Cerebral calcification
Disease(s) Associated with AMER1
osteopathia striata with cranial sclerosis

Mouse Phenotypes
skeleton phenotype
abnormal osteoblast differentiation
abnormal cranial suture morphology
enlarged cranium
increased cranium width
abnormal neurocranium morphology
large fontanelles
enlarged neurocranium
abnormal deltoid tuberosity morphology
absent deltoid tuberosity
bowed radius
increased radius size
abnormal ulna morphology
bowed ulna
abnormal skeleton morphology
abnormal appendicular skeleton morphology
abnormal long bone morphology
abnormal sternum morphology
abnormal sternum ossification
abnormal bone structure
increased bone mineral density
increased bone volume
abnormal compact bone morphology
increased osteoblast cell number
abnormal trabecular bone morphology
increased trabecular bone thickness
osteosclerosis
abnormal skeleton development
abnormal bone mineralization
delayed bone mineralization
increased bone mineralization
abnormal endochondral bone ossification
delayed endochondral bone ossification
abnormal intramembranous bone ossification
delayed intramembranous bone ossification
delayed fontanelle closure
increased bone ossification
Availability Mouse Genotype
Amer1tm1.2Nbar/Amer1+
Amer1tm1.2Nbar/Y
Amer1tm1.1Nbar/Y
Tg(Prrx1-cre)1Cjt/0  (conditional)
Amer1tm1.1Nbar/Y
Tg(Col2a1-cre)1Bhr/0  (conditional)		 *
Amer1tm1.1Nbar/Y
Tg(BGLAP-cre)1Clem/0  (conditional)		 *
Amer1tm1.1Nbar/Y
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0  (conditional)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory