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Symbol
Name
ID

Hdac8
histone deacetylase 8
MGI:1917565

Phenotype annotations related to skeleton

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes

Brachycephaly

Micrognathia

Retrognathia

Malar prominence

Microcephaly

Short neck

Clinodactyly of the 5th finger

Proximal placement of thumb

Tapered finger

Toe syndactyly

Short foot

Small hand

Limited elbow extension

Disease(s) Associated with HDAC8

Cornelia de Lange syndrome 5

Wilson-Turner syndrome

Mouse Phenotypes		frontal bone foramen	decreased bone mineral content	decreased bone mineral density	failure of intramembranous bone ossification
Availability	Mouse Genotype	frontal bone foramen	decreased bone mineral content	decreased bone mineral density	failure of intramembranous bone ossification
	Hdac8^tm1.2Eno/Hdac8^tm1.2Eno	!			!
	Hdac8^{tm1a(EUCOMM)Wtsi}/Hdac8^{tm1a(EUCOMM)Wtsi}
	Hdac8^tm1.2Eno/Hdac8⁺	!			!
	Hdac8^tm1.2Eno/Y	!			!
	Hdac8^{tm1a(EUCOMM)Wtsi}/Y
	Hdac8^tm1.1Eno/Y H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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