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Symbol Name ID |
Mpc1
mitochondrial pyruvate carrier 1 MGI:1915240 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Increased serum pyruvate |
Hypoglycemia |
Increased circulating lactate concentration |
Lactic acidosis |
Organic aciduria |
| Disease(s) Associated with MPC1 | |||||
| mitochondrial pyruvate carrier deficiency |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
increased fatty acid oxidation |
decreased circulating glucose level |
increased circulating ketone body level |
increased circulating lactate level |
decreased circulating cholesterol level |
decreased circulating triglyceride level |
decreased respiratory quotient |
abnormal glucose homeostasis |
abnormal gluconeogenesis |
improved glucose tolerance |
increased insulin sensitivity |
increased triglyceride level |
abnormal metabolism |
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| Availability | Mouse Genotype | ||||||||||||||
| Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
* | ||||||||||||||
| Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi (conditional) | |||||||||||||||
| Mpc1tm1c(EUCOMM)Wtsi/Mpc1tm1c(EUCOMM)Wtsi Tg(Six3-cre)69Frty/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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