Symbol Name ID |
Sdhb
succinate dehydrogenase complex, subunit B, iron sulfur (Ip) MGI:1914930 |
Darker colors indicate more annotations |
Human Phenotypes | Decreased activity of mitochondrial complex II |
Abnormal mitochondria in muscle tissue |
Hypercalcemia |
Increased circulating lactate concentration |
Stress/infection-induced lactic acidosis |
Elevated lactate:pyruvate ratio |
Increased intramyocellular lipid droplets |
Proteinuria |
Elevated urinary catecholamine level |
Elevated urinary norepinephrine level |
Elevated circulating catecholamine level |
Exercise intolerance |
Disease(s) Associated with SDHB | ||||||||||||
mitochondrial complex II deficiency | ||||||||||||
paraganglioma | ||||||||||||
pheochromocytoma |
Mouse Phenotypes | decreased insulin secretion |
increased fasting circulating glucose level |
hyperglycemia |
decreased circulating insulin level |
impaired glucose tolerance |
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Availability | Mouse Genotype | |||||
Sdhbtm1b(EUCOMM)Hmgu/Sdhb+ | ||||||
Sdhbtm1c(EUCOMM)Hmgu/Sdhbtm1c(EUCOMM)Hmgu Tg(Ins2-cre)23Herr/0 (conditional) |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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