About Help FAQ

Symbol
Name
ID

Tk2
thymidine kinase 2, mitochondrial
MGI:1913266

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes	Decreased activity of mitochondrial ATP synthase complex	Decreased activity of mitochondrial complex I	Decreased activity of mitochondrial complex III	Decreased activity of mitochondrial complex IV	Elevated circulating creatine kinase concentration	Increased circulating lactate concentration	Lactic acidosis	Aminoaciduria	Exercise intolerance
Disease(s) Associated with TK2	Decreased activity of mitochondrial ATP synthase complex	Decreased activity of mitochondrial complex I	Decreased activity of mitochondrial complex III	Decreased activity of mitochondrial complex IV	Elevated circulating creatine kinase concentration	Increased circulating lactate concentration	Lactic acidosis	Aminoaciduria	Exercise intolerance
autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 3
mitochondrial DNA depletion syndrome 2

Mouse Phenotypes		abnormal adaptive thermogenesis	decreased body temperature
Availability	Mouse Genotype
	Tk2^tm1Anka/Tk2^tm1Anka

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23