Symbol
Name
ID

Pcdh15
protocadherin 15
MGI:1891428

Phenotype annotations related to hearing/vestibular/ear

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Abnormal vestibular function	Sensorineural hearing impairment	Congenital sensorineural hearing impairment	Hearing impairment
Disease(s) Associated with PCDH15	Abnormal vestibular function	Sensorineural hearing impairment	Congenital sensorineural hearing impairment	Hearing impairment
autosomal recessive nonsyndromic deafness 23
Usher syndrome type 1D
Usher syndrome type 1F

Mouse Phenotypes

hearing/vestibular/ear phenotype

abnormal vestibuloocular dark reflex

abnormal vestibuloocular light reflex

abnormal inner hair cell kinocilium morphology

abnormal inner hair cell kinocilium location or orientation

abnormal outer hair cell kinocilium morphology

abnormal outer hair cell kinocilium location or orientation

abnormal vestibular hair cell kinocilium morphology

abnormal cochlear sensory epithelium morphology

abnormal cochlear hair cell morphology

abnormal cochlear hair cell stereociliary bundle morphology

abnormal cochlear hair cell inter-stereocilial links morphology

abnormal cochlear hair bundle tip links morphology

abnormal inner hair cell stereociliary bundle morphology

abnormal orientation of inner hair cell stereociliary bundles

decreased inner hair cell stereocilia number

fused inner hair cell stereocilia

short inner hair cell stereocilia

abnormal orientation of cochlear hair cell stereociliary bundles

abnormal orientation of outer hair cell stereociliary bundles

abnormal outer hair cell stereociliary bundle morphology

short outer hair cell stereocilia

decreased outer hair cell stereocilia number

short cochlear hair cell stereocilia

cochlear inner hair cell degeneration

abnormal cochlear outer hair cell morphology

cochlear outer hair cell degeneration

cochlear hair cell degeneration

abnormal organ of Corti morphology

abnormal organ of Corti supporting cell morphology

abnormal Hensen cell morphology

abnormal pillar cell morphology

absent tunnel of Corti

organ of Corti degeneration

vestibular hair cell degeneration

abnormal vestibular saccule morphology

vestibular saccular macula degeneration

vestibular saccular degeneration

abnormal otolithic membrane morphology

abnormal otolith morphology

decreased otolith number

enlarged otoliths

abnormal hair cell mechanoelectric transduction

abnormal auditory brainstem response

increased or absent threshold for auditory brainstem response

abnormal cochlear nerve compound action potential

absent distortion product otoacoustic emissions

deafness

abnormal vestibular system physiology

absent linear vestibular evoked potential

Availability

Mouse Genotype

Pcdh15^av-2J/Pcdh15^av-2J

Pcdh15^av-3J/Pcdh15^av-3J

Pcdh15^av-5J/Pcdh15^av-5J

Pcdh15^av-6J/Pcdh15^av-6J

Pcdh15^av-J/Pcdh15^av-J

Pcdh15^av-Jfb/Pcdh15^av-Jfb

Pcdh15^av-Tg2742Rpw/Pcdh15^av-Tg2742Rpw

Pcdh15^av/Pcdh15^av

Pcdh15^em1Zma/Pcdh15^em1Zma

Pcdh15^roda/Pcdh15^roda

Pcdh15^tm1.1Mll/Pcdh15^tm1.1Mll

Pcdh15^tm2.1Mll/Pcdh15^tm2.1Mll

Pcdh15^tm3.1Mll/Pcdh15^tm3.1Mll

Pcdh15^av-3J/Pcdh15⁺

Pcdh15^tm1.1Ugds/Pcdh15^tm1.1Ugds
Myo15a^{tm1.1(cre)Ugds}/Myo15a⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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