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Symbol
Name
ID
Nbn
nibrin
MGI:1351625
Phenotype annotations related to cellular
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Dysgammaglobulinemia
Disease(s) Associated with NBN
Nijmegen breakage syndrome

Mouse Phenotypes
cellular phenotype
decreased oocyte number
absent oocytes
abnormal cell cycle
abnormal cell cycle checkpoint function
abnormal inner cell mass apoptosis
increased apoptosis
decreased cellular sensitivity to ionizing radiation
increased cellular sensitivity to gamma-irradiation
abnormal neuron differentiation
decreased B cell proliferation
decreased fibroblast proliferation
decreased inner cell mass proliferation
absent inner cell mass proliferation
chromosomal instability
chromosome breakage
Availability Mouse Genotype
Nbntm1Jpt/Nbntm1Jpt *
Nbntm1Nus/Nbntm1Nus
Nbntm1Xu/Nbntm1Xu
Nbntm1Zqw/Nbntm1Zqw
Nbntm2.1Jpt/Nbntm2.1Jpt
Nbntm3Jpt/Nbntm3Jpt
Nbntm1Zqw/Nbn+
Nbntm2Zqw/Nbntm2Zqw
Tg(Nes-cre)1Wme/0  (conditional)
Nbntm1Md/Nbntm1Zqw
Tg(Mx1-cre)1Cgn/0  (conditional)
Nbntm1Nus/Nbntm2Nus
Tg(CD19-cre/ERT2)1Cgn/0  (conditional)
Nbntm1Nus/Nbntm2Nus
Tg(Spo11-cre)D5Mpel/0  (conditional)
Nbntm2Zqw/Nbntm2.1Zqw
Tg(Nes-cre)1Wme/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory