Symbol
Name
ID

Nbn
nibrin
MGI:1351625

Phenotype annotations related to cellular

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Dysgammaglobulinemia	Abnormality of chromosome stability
Disease(s) Associated with NBN	Dysgammaglobulinemia	Abnormality of chromosome stability
Nijmegen breakage syndrome

Mouse Phenotypes

cellular phenotype

decreased oocyte number

absent oocytes

abnormal cell cycle

abnormal cell cycle checkpoint function

decreased cellular sensitivity to ionizing radiation

increased cellular sensitivity to ionizing radiation

increased cellular sensitivity to gamma-irradiation

abnormal inner cell mass apoptosis

increased apoptosis

abnormal neuron differentiation

decreased B cell proliferation

decreased fibroblast proliferation

decreased inner cell mass proliferation

absent inner cell mass proliferation

chromosomal instability

chromosome breakage

Availability

Mouse Genotype

Nbn^em3Jpt/Nbn^em3Jpt

Nbn^em4Jpt/Nbn^em4Jpt

Nbn^tm1Jpt/Nbn^tm1Jpt

Nbn^tm1Nus/Nbn^tm1Nus

Nbn^tm1Xu/Nbn^tm1Xu

Nbn^tm1Zqw/Nbn^tm1Zqw

Nbn^tm2.1Jpt/Nbn^tm2.1Jpt

Nbn^tm3Jpt/Nbn^tm3Jpt

Nbn^tm1Zqw/Nbn⁺

Nbn^tm2Zqw/Nbn^tm2Zqw
Tg(Nes-cre)1Wme/0 (conditional)

Nbn^tm1Md/Nbn^tm1Zqw
Tg(Mx1-cre)1Cgn/0 (conditional)

Nbn^tm1Nus/Nbn^tm2Nus
Tg(CD19-cre/ERT2)1Cgn/0 (conditional)

Nbn^tm1Nus/Nbn^tm2Nus
Tg(Spo11-cre)D5Mpel/0 (conditional)

Nbn^tm2Zqw/Nbn^tm2.1Zqw
Tg(Nes-cre)1Wme/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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