Symbol
Name
ID

Casr
calcium-sensing receptor
MGI:1351351

Phenotype annotations related to skeleton

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Chondrocalcinosis	Reduced bone mineral density	Osteopenia	Generalized osteoporosis	Basal ganglia calcification
Disease(s) Associated with CASR	Chondrocalcinosis	Reduced bone mineral density	Osteopenia	Generalized osteoporosis	Basal ganglia calcification
autosomal dominant hypocalcemia
autosomal dominant hypocalcemia 1
hyperparathyroidism

Mouse Phenotypes

skeleton phenotype

abnormal skeleton morphology

increased width of hypertrophic chondrocyte zone

kyphoscoliosis

decreased bone mineral content

decreased bone mineral density

decreased compact bone volume

decreased trabecular bone volume

decreased compact bone thickness

abnormal trabecular bone morphology

decreased bone trabecula number

decreased trabecular bone connectivity density

decreased trabecular bone thickness

abnormal skeleton development

abnormal bone mineralization

decreased bone mineralization

rickets

delayed bone ossification

fragile skeleton

Availability

Mouse Genotype

Casr^tm1Ces/Casr^tm1Ces

Casr^tm1Ces/Casr⁺

Casr^tm1Wch/Casr^tm1Wch
Tg(PTH-cre)4167Slib/0 (conditional)

Casr^tm1Wch/Casr^tm1Wch
Tg(Col1a1-cre)2Bek/0 (conditional)

Casr^tm1Wch/Casr^tm1Wch
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0 (conditional)

Casr^tm1Wch/Casr^tm1Wch
Tg(Col2a1-cre)1Bhr/0 (conditional)

Casr^tm1Wch/Casr^tm1Wch
Tg(Col2a1-cre/ERT)KA3Smac/0 (conditional)

Casr^tm1Wch/Casr⁺
Tg(PTH-cre)4167Slib/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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