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Symbol
Name
ID
Casr
calcium-sensing receptor
MGI:1351351
Phenotype annotations related to skeleton
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Basal ganglia calcification
Disease(s) Associated with CASR
autosomal dominant hypocalcemia 1

Mouse Phenotypes
skeleton phenotype
abnormal skeleton morphology
increased width of hypertrophic chondrocyte zone
kyphoscoliosis
decreased bone mineral content
decreased bone mineral density
decreased compact bone volume
decreased trabecular bone volume
decreased compact bone thickness
abnormal trabecular bone morphology
decreased bone trabecula number
decreased trabecular bone connectivity density
decreased trabecular bone thickness
abnormal skeleton development
abnormal bone mineralization
decreased bone mineralization
rickets
delayed bone ossification
fragile skeleton
Availability Mouse Genotype
Casrtm1Ces/Casrtm1Ces
Casrtm1Ces/Casr+ *
Casrtm1Wch/Casrtm1Wch
Tg(PTH-cre)4167Slib/0  (conditional)
Casrtm1Wch/Casrtm1Wch
Tg(Col1a1-cre)2Bek/0  (conditional)
Casrtm1Wch/Casrtm1Wch
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0  (conditional)
*
Casrtm1Wch/Casrtm1Wch
Tg(Col2a1-cre)1Bhr/0  (conditional)
Casrtm1Wch/Casrtm1Wch
Tg(Col2a1-cre/ERT)KA3Smac/0  (conditional)
Casrtm1Wch/Casr+
Tg(PTH-cre)4167Slib/0  (conditional)
*

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory