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Symbol Name ID |
Aifm1
apoptosis-inducing factor, mitochondrion-associated 1 MGI:1349419 |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased activity of mitochondrial complex IV |
| Disease(s) Associated with AIFM1 | |
| combined oxidative phosphorylation deficiency 6 |
| Mouse Phenotypes | increased cardiomyocyte apoptosis |
abnormal mitochondrial morphology |
abnormal mitochondrial crista morphology |
increased mitochondrial number |
abnormal cell physiology |
abnormal cell cycle |
increased cellular sensitivity to hydrogen peroxide |
increased embryonic tissue cell apoptosis |
decreased neuron apoptosis |
decreased susceptibility to neuronal excitotoxicity |
increased neuron apoptosis |
abnormal aerobic respiration |
abnormal respiratory electron transport chain |
abnormal mitochondrial ATP synthesis coupled electron transport |
abnormal mitochondrial physiology |
decreased mitochondrial fission |
oxidative stress |
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| Availability | Mouse Genotype | |||||||||||||||||
| Aifm1Hq/Aifm1Hq | ||||||||||||||||||
| Aifm1tm2.1Pngr/Aifm1tm2.1Pngr | ||||||||||||||||||
| Aifm1Hq/Y | ||||||||||||||||||
| Aifm1tm1Pngr/Y | ||||||||||||||||||
| Aifm1tm2.1Pngr/Y | ||||||||||||||||||
| Aifm1tm2Pngr/Y Foxg1tm1(cre)Skm/Foxg1+ (conditional) |
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| Aifm1tm2Pngr/Y Tg(Ckmm-cre)5Khn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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