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Symbol
Name
ID

Gpc6
glypican 6
MGI:1346322

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Frontal bossing

Craniosynostosis

Micrognathia

Malar flattening

Short neck

Abnormal femur morphology

Fibular hypoplasia

Increased fibular diameter

Short tibia

Abnormal metaphysis morphology

Abnormal morphology of the radius

Anterolateral radial head dislocation

Hypoplastic distal humeri

Short humerus

Limited knee extension

Limited knee flexion

Limited knee flexion/extension

Elbow dislocation

Limited elbow extension

Limited elbow flexion/extension

Limited elbow flexion

Mesomelia

Micromelia

Rhizomelia

Pterygium

Axillary pterygium

Popliteal pterygium

Limited hip movement

Disease(s) Associated with GPC6

omodysplasia 1

Mouse Phenotypes		decreased chondrocyte proliferation	small cranium	short femur	short fibula	short tibia	abnormal long bone diaphysis morphology	abnormal long bone epiphyseal plate proliferative zone	decreased length of long bones
Availability	Mouse Genotype	decreased chondrocyte proliferation	small cranium	short femur	short fibula	short tibia	abnormal long bone diaphysis morphology	abnormal long bone epiphyseal plate proliferative zone	decreased length of long bones
	Gpc6^tm1Lex/Gpc6^tm1Lex
	Gpc6^{tm2c(EUCOMM)Wtsi}/Gpc6^{tm2c(EUCOMM)Wtsi} Tg(Col2a1-cre)1Bhr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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