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Symbol Name ID |
Ppargc1a
peroxisome proliferative activated receptor, gamma, coactivator 1 alpha MGI:1342774 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Type II diabetes mellitus |
Insulin resistance |
Hepatic steatosis |
| Disease(s) Associated with PPARGC1A | |||
| metabolic dysfunction-associated steatotic liver disease | |||
| type 2 diabetes mellitus |
| Mouse Phenotypes | homeostasis/metabolism phenotype |
increased response of heart to induced stress |
impaired autophagy |
decreased susceptibility to diet-induced obesity |
impaired adaptive thermogenesis |
abnormal blood homeostasis |
decreased circulating glucose level |
hypoglycemia |
increased circulating glucose level |
hyperglycemia |
decreased circulating insulin level |
decreased circulating cholesterol level |
increased circulating interleukin-6 level |
increased circulating alkaline phosphatase level |
decreased nervous system dopamine level |
decreased dopamine level |
decreased oxygen consumption |
increased oxygen consumption |
decreased respiratory quotient |
abnormal glucose homeostasis |
abnormal gluconeogenesis |
impaired glucose tolerance |
improved glucose tolerance |
increased insulin sensitivity |
insulin resistance |
abnormal lipid homeostasis |
decreased liver triglyceride level |
decreased triglyceride level |
increased basal metabolism |
increased incidence of tumors by chemical induction |
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| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||
| Ppargc1atm1.1Amos/Ppargc1atm1.1Amos | |||||||||||||||||||||||||||||||
| Ppargc1atm1Aztc/Ppargc1atm1Aztc | |||||||||||||||||||||||||||||||
| Ppargc1atm1Brsp/Ppargc1atm1Brsp | |||||||||||||||||||||||||||||||
| Ppargc1atm1Dpk/Ppargc1atm1Dpk | |||||||||||||||||||||||||||||||
| Ppargc1atm1Aztc/Ppargc1a+ | |||||||||||||||||||||||||||||||
| Ppargc1atm1Brsp/Ppargc1a+ | |||||||||||||||||||||||||||||||
| Tg(Myog-Ppargc1a_i4)#Brsp/0 | |||||||||||||||||||||||||||||||
| Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp Tg(Myog-cre)1Eno/0 (conditional) |
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| Ppargc1atm2.1Brsp/Ppargc1atm2.1Brsp (conditional) | |||||||||||||||||||||||||||||||
| Ppargc1atm2Brsp/Ppargc1atm2Brsp Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ (conditional) |
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| Ppargc1atm1Brsp/Ppargc1atm2Brsp Tg(Myog-cre)1Eno/0 (conditional) |
* | ||||||||||||||||||||||||||||||
| Ppargc1atm2Brsp/Ppargc1a+ Tg(Myog-cre)1Eno/0 (conditional) |
* | ||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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