Symbol
Name
ID

Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
MGI:1341830

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Hyponatremia

Decreased level of 1,5 anhydroglucitol in serum

Hyperbilirubinemia

Hyperammonemia

Hypoalbuminemia

Elevated circulating hepatic transaminase concentration

Hyperglycemia

Diabetes mellitus

Insulin-resistant diabetes mellitus

Neonatal insulin-dependent diabetes mellitus

Type I diabetes mellitus

Ketoacidosis

Dehydration

Fever

Ascites

Disease(s) Associated with EIF2AK3

type 1 diabetes mellitus

Wolcott-Rallison syndrome

Mouse Phenotypes		homeostasis/metabolism phenotype	steatorrhea	abnormal insulin secretion	hyperglycemia	decreased circulating insulin level	increased circulating amylase level	impaired glucose tolerance	increased liver glycogen level	increased physiological sensitivity to xenobiotic
Availability	Mouse Genotype	homeostasis/metabolism phenotype	steatorrhea	abnormal insulin secretion	hyperglycemia	decreased circulating insulin level	increased circulating amylase level	impaired glucose tolerance	increased liver glycogen level	increased physiological sensitivity to xenobiotic
	Eif2ak3^tm1Drc/Eif2ak3^tm1Drc
	Eif2ak3^tm1Dron/Eif2ak3^tm1Dron
	Eif2ak3^tm1Dron/Eif2ak3⁺
	Eif2ak3^tm1.1Drc/Eif2ak3^tm1.1Drc Tg(Ela1-cre)16Eps/0 (conditional)	*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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