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Symbol
Name
ID
Trp63
transformation related protein 63
MGI:1330810
Phenotype annotations related to craniofacial
Darker colors indicate more annotations
Human Phenotypes
Abnormality of dental enamel
Micrognathia
Hypoplasia of the maxilla
Malar flattening
Oval face
High forehead
Cleft upper lip
Non-midline cleft lip
Cleft palate
Submucous cleft soft palate
Submucous cleft hard palate
Bifid uvula
Velopharyngeal insufficiency
Absence of Stensen duct
Narrow mouth
Hypodontia
Oligodontia
Selective tooth agenesis
Delayed eruption of teeth
Conical tooth
Small, conical teeth
Microdontia
Carious teeth
Widely spaced teeth
Premature loss of permanent teeth
Oral cleft
Xerostomia
Underdeveloped nasal alae
Narrow nose
Choanal atresia
Depressed nasal tip
Depressed nasal bridge
Wide nasal bridge
Abnormality of the nasopharynx
Conjunctivitis
Sparse and thin eyebrow
Absent eyelashes
Sparse eyelashes
Blepharophimosis
Ankyloblepharon
Blepharitis
Lacrimal duct atresia
Nasolacrimal duct obstruction
Absent lacrimal punctum
Dacryocystitis
Alopecia of scalp
Sparse scalp hair
Disease(s) Associated with TP63
ADULT syndrome
ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3
Rapp-Hodgkin syndrome

Mouse Phenotypes
abnormal craniofacial morphology
absent tooth placode
absent teeth
small mandible
small maxilla
abnormal craniofacial development
abnormal secondary palate development
abnormal facial morphology
cleft palate
abnormal tongue epithelium morphology
absent tongue squamous epithelium
abnormal olfactory epithelium morphology
abnormal horizontal basal cell of olfactory epithelium morphology
Availability Mouse Genotype
Trp63m1Mhda/Trp63m1Mhda
Trp63tm1.1(cre)Ssig/Trp63tm1.1(cre)Ssig
Trp63tm1Aam/Trp63tm1Aam
Trp63tm1Brd/Trp63tm1Brd
Trp63tm1Fmc/Trp63tm1Fmc
Trp63tm1Sin/Trp63tm1Sin
Trp63tm2Brd/Trp63tm2Brd
Trp63tm1Cmis/Trp63+
Trp63tm2Brd/Trp63+
Tg(KRT5-cre/PGR)1Der/0
Trp63tm2Brd/Trp63tm3.1Brd  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory