|
Symbol Name ID |
Trp63
transformation related protein 63 MGI:1330810 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Alopecia of scalp |
Sparse scalp hair |
Micrognathia |
Hypoplasia of the maxilla |
Malar flattening |
Microcephaly |
Abnormality of the face |
Oval face |
Abnormality of the forehead |
High forehead |
Cleft upper lip |
Non-midline cleft of the upper lip |
Cleft lip |
Submucous cleft hard palate |
Bifid uvula |
Submucous cleft soft palate |
Velopharyngeal insufficiency |
Cleft palate |
Absence of Stensen duct |
Narrow mouth |
Taurodontia |
Conical tooth |
Small, conical teeth |
Microdontia |
Hypodontia |
Oligodontia |
Selective tooth agenesis |
Delayed eruption of teeth |
Abnormal dental enamel morphology |
Enamel hypoplasia |
Carious teeth |
Premature loss of permanent teeth |
Widely spaced teeth |
Orofacial cleft |
Xerostomia |
Choanal atresia |
Bilateral choanal atresia |
Underdeveloped nasal alae |
Depressed nasal tip |
Depressed nasal bridge |
Wide nasal bridge |
Narrow nose |
Abnormal nasopharynx morphology |
Abnormality of the orbital region |
Conjunctivitis |
Sparse eyebrow |
Absent eyelashes |
Sparse eyelashes |
Blepharophimosis |
Ankyloblepharon |
Blepharitis |
Lacrimal duct atresia |
Nasolacrimal duct obstruction |
Lacrimal duct stenosis |
Absent lacrimal punctum |
Dacryocystitis |
| Disease(s) Associated with TP63 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ADULT syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ankyloblepharon-ectodermal defects-cleft lip/palate syndrome | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| bladder exstrophy-epispadias-cloacal exstrophy complex | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Rapp-Hodgkin syndrome |
| Mouse Phenotypes | craniofacial phenotype |
abnormal craniofacial morphology |
abnormal tooth development |
absent tooth placode |
absent teeth |
supernumerary teeth |
abnormal tooth root morphology |
small mandible |
small maxilla |
abnormal craniofacial development |
abnormal secondary palate development |
abnormal palatal shelf fusion at midline |
abnormal facial morphology |
cleft palate |
abnormal tongue epithelium morphology |
absent tongue squamous epithelium |
abnormal olfactory epithelium morphology |
abnormal horizontal basal cell of olfactory epithelium morphology |
|
| Availability | Mouse Genotype | ||||||||||||||||||
| Trp63m1Mhda/Trp63m1Mhda | |||||||||||||||||||
| Trp63tm1.1(cre)Ssig/Trp63tm1.1(cre)Ssig | |||||||||||||||||||
| Trp63tm1Aam/Trp63tm1Aam | |||||||||||||||||||
| Trp63tm1Brd/Trp63tm1Brd | |||||||||||||||||||
| Trp63tm1Fmc/Trp63tm1Fmc | |||||||||||||||||||
| Trp63tm1Sin/Trp63tm1Sin | |||||||||||||||||||
| Trp63tm2Brd/Trp63tm2Brd | |||||||||||||||||||
| Trp63tm1Cmis/Trp63+ | |||||||||||||||||||
| Trp63tm2.1Aam/Trp63tm3.1Aam | |||||||||||||||||||
| Trp63tm2.1Aam/Trp63tm3.2Aam | |||||||||||||||||||
| Trp63tm2.1Aam/Trp63tm3Aam | |||||||||||||||||||
| Trp63tm2Brd/Trp63+ | |||||||||||||||||||
| Trp63tm3.1Aam/Trp63+ | |||||||||||||||||||
| Trp63tm3.2Aam/Trp63+ | * | ||||||||||||||||||
| Trp63tm3Aam/Trp63+ | |||||||||||||||||||
| Tg(KRT5-cre/PGR)1Der/0 Trp63tm2Brd/Trp63tm3.1Brd (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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