Symbol
Name
ID

Men1
multiple endocrine neoplasia 1
MGI:1316736

Phenotype annotations related to neoplasm

Darker colors indicate more annotations

Human Phenotypes

Adenoma sebaceum

Gingival fibromatosis

Breast carcinoma

Thymoma

Colon cancer

Neoplasm of the liver

Pancreatic islet cell adenoma

Insulinoma

Neoplasm of the pancreas

Pancreatic adenocarcinoma

Intestinal carcinoid

Zollinger-Ellison syndrome

Adrenocortical adenoma

Adrenocortical carcinoma

Pituitary adenoma

Pituitary corticotropic cell adenoma

Pituitary gonadotropic cell adenoma

Pituitary growth hormone cell adenoma

Pituitary null cell adenoma

Pituitary prolactin cell adenoma

Pituitary thyrotropic cell adenoma

Parathyroid adenoma

Parathyroid carcinoma

Thyroid adenoma

Hurthle cell thyroid adenoma

Thyroid carcinoma

Carcinoid tumor

Pulmonary carcinoid tumor

Pancreatic endocrine tumor

Glucagonoma

Pheochromocytoma

Ovarian carcinoma

Nephroblastoma

Papillary renal cell carcinoma

Renal cortical adenoma

Subcutaneous lipoma

Multiple lipomas

Ependymoma

Meningioma

Angiofibromas

Hamartoma

Melanoma

Disease(s) Associated with MEN1

hyperparathyroidism

multiple endocrine neoplasia type 1

pancreatic cancer

Mouse Phenotypes

increased gastrointestinal tumor incidence

increased intestinal adenoma incidence

increased stomach tumor incidence

increased mammary gland tumor incidence

increased gland tumor incidence

increased adrenal gland tumor incidence

increased adrenal cortical tumor incidence

increased adrenocortical adenoma incidence

increased adrenal gland adenoma incidence

increased pheochromocytoma incidence

increased ovary tumor incidence

increased pancreas tumor incidence

increased pancreas adenoma incidence

increased pancreatic islet cell adenoma incidence

increased glucagonoma incidence

increased insulinoma incidence

increased pancreatic islet cell carcinoma incidence

increased parathyroid gland tumor incidence

increased parathyroid adenoma incidence

increased pituitary gland tumor incidence

increased pituitary adenohypophysis tumor incidence

increased prolactinoma incidence

increased pituitary adenoma incidence

increased testis tumor incidence

increased Leydig cell tumor incidence

increased thyroid tumor incidence

increased thyroid adenoma incidence

increased thyroid carcinoma incidence

increased carcinoma incidence

increased lung adenocarcinoma incidence

increased gonad tumor incidence

increased lung tumor incidence

increased tumor incidence

Availability

Mouse Genotype

Men1^tm1.1Ctre/Men1⁺

Men1^tm1.1Gfk/Men1⁺

Men1^tm1Ctre/Men1⁺

Men1^tm1Rvt/Men1⁺

Men1^tm1Zqw/Men1⁺

Men1^tm2.1Gfk/Men1⁺

Men1^tm1.2Ctre/Men1^tm1.2Ctre
Tg(Ins2-cre)1Heed/0 (conditional)

Men1^tm1.2Ctre/Men1^tm1.2Ctre
Tg(Ins2-cre)1Dh/0 (conditional)

Men1^tm1.2Ctre/Men1^tm1.2Ctre
Tg(Ins2-cre)25Mgn/0 (conditional)

Men1^tm1.2Zqw/Men1^tm1.2Zqw
Tg(Ins2-cre)23Herr/0 (conditional)

Men1^tm1Ctre/Men1^tm1Ctre
Tg(Pdx1-cre)89.1Dam/0 (conditional)

Men1^tm1Gfk/Men1^tm1Gfk
Tg(Ins2-cre)25Mgn/0 (conditional)

Men1^tm2.1Mmey/Men1^tm2.1Mmey
Tg(Ins2-cre)23Herr/0 (conditional)

Men1^tm1.2Ctre/Men1⁺
Tg(Ins2-cre)1Heed/0 (conditional)

Men1^tm1.2Ctre/Men1⁺
Tg(Ins2-cre)1Dh/0 (conditional)

Men1^tm1.2Ctre/Men1⁺
Tg(Ins2-cre)25Mgn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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