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Symbol
Name
ID
Rasgrp1
RAS guanyl releasing protein 1
MGI:1314635
Phenotype annotations related to immune system
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations

Mouse Phenotypes
immune system phenotype
decreased T cell proliferation
decreased thymocyte number
abnormal T cell differentiation
abnormal CD4-positive T cell differentiation
abnormal CD8-positive, alpha-beta T cell differentiation
abnormal positive T cell selection
abnormal double-positive T cell morphology
increased neutrophil cell number
increased B-1b cell number
increased plasma cell number
decreased B cell number
increased B cell number
increased NK cell number
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number
increased central memory CD4-positive, alpha-beta T cell number
increased effector memory CD4-positive, alpha-beta T cell number
increased CD4-positive, alpha-beta memory T cell number
decreased CD4-positive, alpha beta T cell number
increased central memory CD8 positive, alpha-beta T cell number
increased effector memory CD8-positive, alpha-beta T cell number
increased CD8-positive, alpha-beta memory T cell number
decreased CD8-positive, naive alpha-beta T cell number
decreased CD8-positive, alpha-beta T cell number
decreased T cell number
decreased single-positive T cell number
increased T cell number
increased single-positive T cell number
abnormal T cell morphology
abnormal CD4-positive, alpha beta T cell morphology
increased spleen weight
enlarged spleen
abnormal immunoglobulin level
increased IgA level
increased IgE level
increased IgG1 level
increased IgG level
decreased IgM level
increased IgM level
increased immunoglobulin level
abnormal T cell physiology
abnormal immune system cell morphology
abnormal immune system organ morphology
abnormal lymph node morphology
enlarged lymph nodes
abnormal immune system physiology
abnormal humoral immune response
autoimmune response
increased susceptibility to systemic lupus erythematosus
increased autoantibody level
increased anti-nuclear antigen antibody level
glomerulonephritis
Availability Mouse Genotype
Rasgrp1lag/Rasgrp1lag
Rasgrp1m1Anu/Rasgrp1m1Anu *
Rasgrp1m1Btlr/Rasgrp1m1Btlr
Rasgrp1m2Anu/Rasgrp1m2Anu *
Rasgrp1m2Btlr/Rasgrp1m2Btlr
Rasgrp1m3Btlr/Rasgrp1m3Btlr
Rasgrp1M4Btlr/Rasgrp1M4Btlr
Rasgrp1m5Btlr/Rasgrp1m5Btlr
Rasgrp1tm1.1Wz/Rasgrp1tm1.1Wz *
Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Rasgrp1m1Anu/Rasgrp1+

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory