Symbol
Name
ID

Lrp6
low density lipoprotein receptor-related protein 6
MGI:1298218

Phenotype annotations related to limbs/digits/tail

!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Palmoplantar hyperhidrosis	Palmar hyperkeratosis
Disease(s) Associated with LRP6	Palmoplantar hyperhidrosis	Palmar hyperkeratosis
tooth agenesis

Mouse Phenotypes

sirenomelia

absent apical ectodermal ridge

abnormal tail bud morphology

small tail bud

abnormal limb morphology

abnormal digit morphology

oligodactyly

forelimb oligodactyly

polydactyly

abnormal forelimb morphology

abnormal hindlimb morphology

short limbs

abnormal caudal vertebrae morphology

caudal vertebral fusion

small caudal vertebrae

short tail

curly tail

kinked tail

Availability

Mouse Genotype

Lrp6^Cd/Lrp6^Cd

Lrp6^Gt(Ex187)Byg/Lrp6^Gt(Ex187)Byg

Lrp6^Gw/Lrp6^Gw

Lrp6^rs/Lrp6^rs

Lrp6^skax26/Lrp6^skax26

Lrp6^tm1.2Cjz/Lrp6^tm1.2Cjz

Lrp6^Cd/Lrp6⁺

Lrp6^Cd/Lrp6^Gt(Ex187)Byg

Lrp6^Gw/Lrp6⁺

Lrp6^skax26/Lrp6⁺

Lrp6^tm1.2Cjz/Lrp6^Gt(Ex187)Byg

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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