About Help FAQ

Symbol
Name
ID

Psen1
presenilin 1
MGI:1202717

Phenotype annotations related to behavior/neurological

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Diminished motivation	Apathy	Abnormal sexual behavior	Inappropriate laughter	Personality changes	Polyphagia	Disinhibition	Motor stereotypy	Hyperorality
Disease(s) Associated with PSEN1	Diminished motivation	Apathy	Abnormal sexual behavior	Inappropriate laughter	Personality changes	Polyphagia	Disinhibition	Motor stereotypy	Hyperorality
Alzheimer's disease 3
frontotemporal dementia
Pick's disease

Mouse Phenotypes		behavior/neurological phenotype	abnormal contextual conditioning behavior	abnormal spatial learning	abnormal long-term spatial reference memory	unresponsive to tactile stimuli	increased startle reflex	increased grip strength
Availability	Mouse Genotype	behavior/neurological phenotype	abnormal contextual conditioning behavior	abnormal spatial learning	abnormal long-term spatial reference memory	unresponsive to tactile stimuli	increased startle reflex	increased grip strength
	Psen1^{tm1.1(KOMP)Vlcg}/Psen1^{tm1.1(KOMP)Vlcg}
	Psen1^tm1Mpm/Psen1^tm1Mpm	*
	Psen1^tm1Tak/Psen1^tm1Tak
	Psen1^{tm1.1(KOMP)Vlcg}/Psen1⁺
	Psen1^tm1Mpm/Psen1^tm1Pcw
	Psen1^tm1Jzt/Psen1^tm1Jzt Tg(Camk2a-cre)T29-1Stl/0 (conditional)
	Psen1^tm1Vln/Psen1^tm1Vln Tg(Thy1-cre)1Vln/0 (conditional)	*
	Psen1^tm2Shn/Psen1^tm2Shn Tg(Camk2a-cre)1Shn/0 (conditional)
	Psen1^tm2Shn/Psen1^tm2.1Shn Tg(Camk2a-cre)1Shn/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23