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Symbol
Name
ID
Crx
cone-rod homeobox
MGI:1194883
Phenotype annotations related to vision/eye
*Aspects of the system are reported to show a normal phenotype.
Darker colors indicate more annotations
Human Phenotypes
Keratoconus
Cataract
Chorioretinal atrophy
Macular hyperpigmentation
Bone spicule pigmentation of the retina
Retinal pigment epithelial atrophy
Cone/cone-rod dystrophy
Abnormal electroretinogram
Undetectable electroretinogram
Pendular nystagmus
Color vision defect
Metamorphopsia
Nyctalopia
Photophobia
Visual impairment
Reduced visual acuity
Blindness
Constriction of peripheral visual field
Peripheral visual field loss
Central scotoma
Disease(s) Associated with CRX
cone-rod dystrophy 2
Leber congenital amaurosis 7

Mouse Phenotypes
vision/eye phenotype
abnormal retinal blood vessel morphology
decreased retinal cone cell number
abnormal horizontal cell morphology
abnormal retinal bipolar cell morphology
abnormal retinal cone bipolar cell morphology
abnormal retinal rod bipolar cell morphology
abnormal retinal photoreceptor morphology
abnormal photoreceptor inner segment morphology
absent photoreceptor inner segment
short photoreceptor inner segment
abnormal photoreceptor outer segment morphology
absent photoreceptor outer segment
abnormal retinal rod cell outer segment morphology
abnormal retinal cone cell morphology
retinal photoreceptor degeneration
abnormal retinal pigmentation
abnormal ocular fundus morphology
abnormal retina morphology
abnormal retinal layer morphology
abnormal retinal outer nuclear layer morphology
abnormal retinal outer nuclear layer thickness
thin retinal outer nuclear layer
retinal outer nuclear layer degeneration
abnormal retinal outer plexiform layer morphology
thin retinal outer plexiform layer
abnormal retinal photoreceptor layer morphology
retinal spots
abnormal electroretinogram waveform feature
decreased a wave amplitude
decreased b wave amplitude
abnormal eye electrophysiology
abnormal cone electrophysiology
abnormal rod electrophysiology
blindness
Availability Mouse Genotype
CrxRip/CrxRip
Crxtm1.1Smgc/Crxtm1.1Smgc *
Crxtm1Clc/Crxtm1Clc *
Crxtm2.1Smgc/Crxtm2.1Smgc *
Crxtvrm65/Crxtvrm65
CrxRip/Crx+ *
Crxtm1.1Smgc/Crx+
Crxtm1Clc/Crx+
Crxtm1Smgc/Crx+ *
Crxtm2.1Smgc/Crx+ *

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory