Symbol
Name
ID

Kl
klotho
MGI:1101771

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased LDL cholesterol concentration	Hypercholesterolemia	Hypertriglyceridemia	Glucose intolerance	Diabetes mellitus	Type II diabetes mellitus	Impaired glucose tolerance
Disease(s) Associated with KL
coronary artery disease

Mouse Phenotypes

homeostasis/metabolism phenotype

decreased insulin secretion

decreased circulating glucose level

hypoglycemia

decreased circulating insulin level

increased circulating noradrenaline level

decreased circulating parathyroid hormone level

increased circulating parathyroid hormone level

abnormal circulating mineral level

increased circulating calcium level

increased circulating phosphate level

abnormal circulating protein level

decreased circulating serum albumin level

decreased body temperature

dehydration

abnormal glucose homeostasis

improved glucose tolerance

increased insulin sensitivity

calcinosis

abnormal vitamin D level

increased vitamin D level

increased urine calcium level

increased alkaline phosphatase activity

Availability

Mouse Genotype

Kl^ecalc1/Kl^ecalc1

Kl^ecalc2/Kl^ecalc2

Kl^kl/Kl^kl

Kl^m1Anu/Kl^m1Anu

Kl^tm1.2Tel/Kl^tm1.2Tel

Kl^tm1Lex/Kl^tm1Lex

Kl^tm1Yin/Kl^tm1Yin

Kl^kl/Kl⁺

Kl^tm1.1Tel/Kl^tm1.1Tel
Tg(Cdh16-cre)91Igr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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